抄録
The methanol extract of heartwood of Artocarpus incisus showed potent 5α-reductase inhibitory activity. We investigated the 5α-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 μM) and artocarpin (IC50 = 85 μM) showed more potent inhibitory effects than did α-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5α-reductase inhibitory effects.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 16-19 |
| ページ数 | 4 |
| ジャーナル | Planta Medica |
| 巻 | 66 |
| 号 | 1 |
| DOI | |
| 出版ステータス | 出版済み - 2000 |
!!!All Science Journal Classification (ASJC) codes
- 植物科学
- 創薬
- 有機化学
- 薬理学