The 5α-reductase inhibitory components from heartwood of Artocarpus incisus: Structure-activity investigations

Kuniyoshi Shimizu; Masayuki Fukuda; Ryuichiro Kondo; Kokki Sakai

doi:10.1055/s-2000-11114

The 5α-reductase inhibitory components from heartwood of Artocarpus incisus: Structure-activity investigations

Kuniyoshi Shimizu, Masayuki Fukuda, Ryuichiro Kondo, Kokki Sakai

サスティナブル資源科学

研究成果: ジャーナルへの寄稿 › 記事

58 引用（Scopus）

抜粋

The methanol extract of heartwood of Artocarpus incisus showed potent 5α-reductase inhibitory activity. We investigated the 5α-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC₅₀ = 37 μM) and artocarpin (IC₅₀ = 85 μM) showed more potent inhibitory effects than did α-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5α-reductase inhibitory effects.

元の言語	英語
ページ（範囲）	16-19
ページ数	4
ジャーナル	Planta Medica
巻	66
発行部数	1
DOI	https://doi.org/10.1055/s-2000-11114
出版物ステータス	出版済み - 2000

フィンガープリント

All Science Journal Classification (ASJC) codes

Plant Science
Drug Discovery
Organic Chemistry
Pharmacology

これを引用

Shimizu, K., Fukuda, M., Kondo, R., & Sakai, K. (2000). The 5α-reductase inhibitory components from heartwood of Artocarpus incisus: Structure-activity investigations. Planta Medica, 66(1), 16-19. https://doi.org/10.1055/s-2000-11114

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文献にアクセス

10.1055/s-2000-11114