The 5α-reductase inhibitory components from heartwood of Artocarpus incisus: Structure-activity investigations

Kuniyoshi Shimizu, Masayuki Fukuda, Ryuichiro Kondo, Kokki Sakai

研究成果: ジャーナルへの寄稿記事

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The methanol extract of heartwood of Artocarpus incisus showed potent 5α-reductase inhibitory activity. We investigated the 5α-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 μM) and artocarpin (IC50 = 85 μM) showed more potent inhibitory effects than did α-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5α-reductase inhibitory effects.

元の言語英語
ページ(範囲)16-19
ページ数4
ジャーナルPlanta Medica
66
発行部数1
DOI
出版物ステータス出版済み - 2000

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All Science Journal Classification (ASJC) codes

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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