The 67 kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG

Yoshinori Fujimura, Daisuke Umeda, Satomi Yano, Mari Maeda-Yamamoto, Koji Yamada, Hirofumi Tachibana

研究成果: Contribution to journalArticle査読

54 被引用数 (Scopus)

抄録

Previously we have reported that the O-methylated derivative of (-)-epigallocatechin-3-O-gallate (EGCG), (-)-epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3"Me), possesses anti-allergic activities such as inhibition of histamine release and suppression of the high-affinity IgE receptor (FcεRI) expression. However, the underlying mechanism is still unclear. Recently we have identified the 67 kDa laminin receptor (67LR) as a cell-surface receptor that can mediate biological activities of EGCG. Here we show that the suppression of myosin II regulatory light chain (MRLC) phosphorylation through the cell-surface binding to the 67 LR contributes to the inhibitory effect of EGCG3"Me on the histamine release from the human basophilic KU812 cells. The 67LR also mediated the EGCG3"Me-induced suppression of FcεRI expression by reducing ERK1/2 phosphorylation. These results suggest that anti-allergic effects of EGCG3"Me may be triggered by the inhibition of MRLC or ERK1/2 phosphorylation mediated through the cell-surface 67LR.

本文言語英語
ページ(範囲)79-85
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
364
1
DOI
出版ステータス出版済み - 12 7 2007

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「The 67 kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル