The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum

Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Shoichiro Kumamoto, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

47 被引用数 (Scopus)

抄録

The anti-androgenic activity of the ethanol extract of the fruiting body of Ganoderma lucidum has been previously reported. Ganoderol B with 5α-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.

本文言語英語
ページ(範囲)4966-4972
ページ数7
ジャーナルBioorganic and Medicinal Chemistry
15
14
DOI
出版ステータス出版済み - 7月 15 2007

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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