The AP-1 transcription factor JunB is required for Th17 cell differentiation

Soh Yamazaki, Yoshihiko Tanaka, Hiromitsu Araki, Akira Kohda, Fumiyuki Sanematsu, Tomoko Arasaki, Xuefeng Duan, Fumihito Miura, Takaharu Katagiri, Ryodai Shindo, Hiroyasu Nakano, Takashi Ito, Yoshinori Fukui, Shogo Endo, Hideki Sumimoto

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Interleukin (IL)-17-producing T helper (Th17) cells are crucial for host defense against extracellular microbes and pathogenesis of autoimmune diseases. Here we show that the AP-1 transcription factor JunB is required for Th17 cell development. Junb-deficient CD4+ T cells are able to develop in vitro into various helper T subsets except Th17. The RNA-seq transcriptome analysis reveals that JunB is crucial for the Th17-specific gene expression program. Junb-deficient mice are completely resistant to experimental autoimmune encephalomyelitis, a Th17-mediated inflammatory disease, and naive T helper cells from such mice fail to differentiate into Th17 cells. JunB appears to activate Th17 signature genes by forming a heterodimer with BATF, another AP-1 factor essential for Th17 differentiation. The mechanism whereby JunB controls Th17 cell development likely involves activation of the genes for the Th17 lineage-specifying orphan receptors RORγt and RORα and reduced expression of Foxp3, a transcription factor known to antagonize RORγt function.

元の言語英語
記事番号17402
ジャーナルScientific reports
7
発行部数1
DOI
出版物ステータス出版済み - 12 1 2017

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Th17 Cells
Transcription Factor AP-1
Cell Differentiation
Helper-Inducer T-Lymphocytes
Autoimmune Experimental Encephalomyelitis
Interleukin-17
Gene Expression Profiling
Transcriptional Activation
Autoimmune Diseases
Transcription Factors
RNA
T-Lymphocytes
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • General

これを引用

The AP-1 transcription factor JunB is required for Th17 cell differentiation. / Yamazaki, Soh; Tanaka, Yoshihiko; Araki, Hiromitsu; Kohda, Akira; Sanematsu, Fumiyuki; Arasaki, Tomoko; Duan, Xuefeng; Miura, Fumihito; Katagiri, Takaharu; Shindo, Ryodai; Nakano, Hiroyasu; Ito, Takashi; Fukui, Yoshinori; Endo, Shogo; Sumimoto, Hideki.

:: Scientific reports, 巻 7, 番号 1, 17402, 01.12.2017.

研究成果: ジャーナルへの寄稿記事

Yamazaki, S, Tanaka, Y, Araki, H, Kohda, A, Sanematsu, F, Arasaki, T, Duan, X, Miura, F, Katagiri, T, Shindo, R, Nakano, H, Ito, T, Fukui, Y, Endo, S & Sumimoto, H 2017, 'The AP-1 transcription factor JunB is required for Th17 cell differentiation', Scientific reports, 巻. 7, 番号 1, 17402. https://doi.org/10.1038/s41598-017-17597-3
Yamazaki, Soh ; Tanaka, Yoshihiko ; Araki, Hiromitsu ; Kohda, Akira ; Sanematsu, Fumiyuki ; Arasaki, Tomoko ; Duan, Xuefeng ; Miura, Fumihito ; Katagiri, Takaharu ; Shindo, Ryodai ; Nakano, Hiroyasu ; Ito, Takashi ; Fukui, Yoshinori ; Endo, Shogo ; Sumimoto, Hideki. / The AP-1 transcription factor JunB is required for Th17 cell differentiation. :: Scientific reports. 2017 ; 巻 7, 番号 1.
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