The arcuate nucleus as a primary site of satiety effect of leptin in rats

Noriko Satoh, Yoshihiro Ogawa, Goro Katsuura, Minoru Hayase, Tetsuo Tsuji, Keiichi Imagawa, Yasunao Yoshimasa, Shigeo Nishi, Kiminori Hosoda, Kazuwa Nakao

研究成果: Contribution to journalArticle

166 引用 (Scopus)

抜粋

The obese (ob) gene encodes a fat cell-derived circulating satiety factor (leptin) that is involved in the regulation of energy homeostasis. In the present study, we examined effects of i.c.v. injection of recombinant human leptin on food intake and body weight gain in rats. We also studied effects of direct microinjections of leptin into the arcuate nucleus (Arc), ventromedial hypothalamus (VMH), and lateral hypothalamus (LH). A single i.c.v. injection of recombinant human leptin (0.25-2.0 μg/rat) reduced significantly and dose-dependently food intake and body weight gain in rats. Microinjections (0.125-0.5 μg/site) into the bilateral Arc, VMH, and LH caused dose-related decreases in food intake and body weight gain as compared with vehicle-treated groups with a rank order of potency; Arc > VMH = LH. The present study provides the first direct evidence that the Arc is a primary site of satiety effect of leptin.

元の言語英語
ページ(範囲)149-152
ページ数4
ジャーナルNeuroscience Letters
224
発行部数3
DOI
出版物ステータス出版済み - 4 10 1997
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

フィンガープリント The arcuate nucleus as a primary site of satiety effect of leptin in rats' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Satoh, N., Ogawa, Y., Katsuura, G., Hayase, M., Tsuji, T., Imagawa, K., Yoshimasa, Y., Nishi, S., Hosoda, K., & Nakao, K. (1997). The arcuate nucleus as a primary site of satiety effect of leptin in rats. Neuroscience Letters, 224(3), 149-152. https://doi.org/10.1016/S0304-3940(97)00163-8