The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells

Akihiro Nita, Yoshiharu Muto, Yuta Katayama, Akinobu Matsumoto, Masaaki Nishiyama, Keiichi I. Nakayama

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Nita et al. reveal that the CHD8-p53 axis plays a key role in regulation of the stemness and differentiation of hematopoietic stem cells (HSCs) in vitro and in vivo. CHD8 deficiency in HSCs results in cell cycle arrest, apoptosis, and a differentiation block, which are partially rescued by additional deletion of p53.

本文言語英語
論文番号108688
ジャーナルCell Reports
34
5
DOI
出版ステータス出版済み - 2 2 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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