The biological response to orthopaedic implants for joint replacement: Part I: Metals

Emmanuel Gibon, Derek F. Amanatullah, Florence Loi, Jukka Pajarinen, Akira Nabeshima, Zhenyu Yao, Moussa Hamadouche, Stuart B. Goodman

研究成果: ジャーナルへの寄稿総説査読

58 被引用数 (Scopus)

抄録

Joint replacement is a commonly performed, highly successful orthopaedic procedure, for which surgeons have a large choice of different materials and implant designs. The materials used for joint replacement must be both biologically acceptable to minimize adverse local tissue reactions, and robust enough to support weight bearing during common activities of daily living. Modern joint replacements are made from metals and their alloys, polymers, ceramics, and composites. This review focuses on the biological response to the different biomaterials used for joint replacement. In general, modern materials for joint replacement are well tolerated by the body as long as they are in bulk (rather than in particulate or ionic) form, are mechanically stable and noninfected. If the latter conditions are not met, the prosthesis will be associated with an acute/chronic inflammatory reaction, peri-prosthetic osteolysis, loosening and failure. This article (Part 1 of 2) is dedicated to the use of metallic devices in orthopaedic surgery including the associated biological response to metallic byproducts is a review of the basic science literature regarding this topic.

本文言語英語
ページ(範囲)2162-2173
ページ数12
ジャーナルJournal of Biomedical Materials Research - Part B Applied Biomaterials
105
7
DOI
出版ステータス出版済み - 10月 2017
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生体材料
  • 生体医工学

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