The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition

Chie Nakashima, Masaaki Shinohara, Hisanori Takagi, Takashi Nakashima, Makoto Kimura

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.

元の言語英語
ページ(範囲)2766-2768
ページ数3
ジャーナルBioscience, Biotechnology and Biochemistry
73
発行部数12
DOI
出版物ステータス出版済み - 12 1 2009

Fingerprint

Ribosomes
Pyrococcus horikoshii
Carrier Proteins
Proteins
Amino Acids
Mutation

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

これを引用

The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition. / Nakashima, Chie; Shinohara, Masaaki; Takagi, Hisanori; Nakashima, Takashi; Kimura, Makoto.

:: Bioscience, Biotechnology and Biochemistry, 巻 73, 番号 12, 01.12.2009, p. 2766-2768.

研究成果: ジャーナルへの寄稿記事

@article{fb918c5386bf4dcda9650284ac4ff068,
title = "The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition",
abstract = "Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.",
author = "Chie Nakashima and Masaaki Shinohara and Hisanori Takagi and Takashi Nakashima and Makoto Kimura",
year = "2009",
month = "12",
day = "1",
doi = "10.1271/bbb.90485",
language = "English",
volume = "73",
pages = "2766--2768",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "12",

}

TY - JOUR

T1 - The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition

AU - Nakashima, Chie

AU - Shinohara, Masaaki

AU - Takagi, Hisanori

AU - Nakashima, Takashi

AU - Kimura, Makoto

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.

AB - Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.

UR - http://www.scopus.com/inward/record.url?scp=74349103417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74349103417&partnerID=8YFLogxK

U2 - 10.1271/bbb.90485

DO - 10.1271/bbb.90485

M3 - Article

VL - 73

SP - 2766

EP - 2768

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 12

ER -