The CCL20 and CCR6 axis in psoriasis

Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Takeshi Nakahara, Masutaka Furue

研究成果: Contribution to journalReview article査読

25 被引用数 (Scopus)

抄録

Psoriasis is a TNF-α/IL-23/IL-17A–mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A–producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A–rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.

本文言語英語
論文番号e12846
ジャーナルScandinavian Journal of Immunology
91
3
DOI
出版ステータス出版済み - 3 1 2020

All Science Journal Classification (ASJC) codes

  • 免疫学

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