The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma

E. Jimi, H. Furuta, K. Matsuo, K. Tominaga, T. Takahashi, O. Nakanishi

研究成果: Contribution to journalReview article査読

58 被引用数 (Scopus)

抄録

Oral squamous cell carcinomas (SCCs) are malignant tumours that frequently invade the mandibular bone and bone invasion is a common clinical problem. Recent studies have revealed that bone resorption by osteoclasts is an important step in the process of bone invasion by oral SCCs. However, the cellular and molecular mechanisms of bone invasion by oral SCCs remain unclear. Oral SCCs invade the mandibular bone through an erosive, mixed or infiltrative pattern that correlates with clinical behaviours. The expressions of interleukin (IL)-6, IL-11, tumour necrosis factor (TNF) α and parathyroid hormone-related protein (PTHrP) were higher in the infiltrative pattern than in the erosive pattern. These cytokines lead to receptor activator of NF-κB ligand (RANKL) expression or osteoprotegerin (OPG) suppression not only in oral SCC cells but also in cancer stromal cells to induce osteoclastogenesis. Taken together, oral SCCs provide a suitable microenvironment for osteoclastogenesis to regulate the balance of RANKL and OPG. In this review, we introduce recent advances in the knowledge of the cellular and molecular mechanisms, by which oral SCC invades mandibular bone based on the recent findings of our lab and others.

本文言語英語
ページ(範囲)462-468
ページ数7
ジャーナルOral Diseases
17
5
DOI
出版ステータス出版済み - 7 1 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 耳鼻咽喉科学
  • 歯科学(全般)

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