The cellular receptor tot measles virus - Elusive no more

Yusuke Yanagi

研究成果: Contribution to journalReview article査読

16 被引用数 (Scopus)

抄録

The identity of the measles virus receptor has been controversial. Several years ago CD46 was identified as a cellular receptor for the Edmonston strain of measles virus, but most clinical isolates of measles virus, which are most efficiently isolated in the marmoset B cell line B95a, cannot grow in many CD46+ cell lines. Although some researchers attributed it to post-entry block in viral replication, others believed that there is a receptor other than CD46 for wild-type measles viruses. A new study showed that human signalling lymphocytic activation molecule (SLAM; also known as CDw150) is a cellular receptor for measles virus, including the Edmonston strain. SLAM is expressed on lymphocytes and dendritic cells, and plays an important role in lymphocyte activation. The identification of SLAM as a measles virus receptor nicely explains the pathogenesis of measles virus infection.

本文言語英語
ページ(範囲)149-156
ページ数8
ジャーナルReviews in Medical Virology
11
3
DOI
出版ステータス出版済み - 2001

All Science Journal Classification (ASJC) codes

  • ウイルス学
  • 感染症

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