The circadian clock transcriptional complex: Metabolic feedback intersects with epigenetic control

Selma Masri, Loredana Zocchi, Sayako Katada, Eugenio Mora, Paolo Sassone-Corsi

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

抄録

Chromatin remodeling is a prerequisite for most nuclear functions, including transcription, silencing, and DNA replication. Accumulating evidence shows that many physiological processes require highly sophisticated events of chromatin remodeling. Recent findings have linked cellular metabolism, epigenetic state, and the circadian clock. The control of a large variety of neuronal, behavioral, and physiological responses follows diurnal rhythms. This is possible through a transcriptional regulatory network that governs a significant portion of the genome. The harmonic oscillation of gene expression is paralleled by critical events of chromatin remodeling that appear to provide specificity and plasticity in circadian regulation. Accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes. These notions indicate that the circadian epigenome might integrate tissue specificity within biological pacemakers, bridging systems physiology to metabolic control. This review highlights several advances related to the circadian epigenome, the contribution of NAD+ as a critical signaling metabolite, and its effects on epigenetic state, followed by more recent reports on circadian metabolomics analyses.

元の言語英語
ページ(範囲)103-109
ページ数7
ジャーナルAnnals of the New York Academy of Sciences
1264
発行部数1
DOI
出版物ステータス出版済み - 8 2012

Fingerprint

Circadian Clocks
Chromatin Assembly and Disassembly
Epigenomics
Chromatin
Clocks
Feedback
Physiological Phenomena
Biological Clocks
Pacemakers
Organ Specificity
Metabolomics
Gene Regulatory Networks
Physiology
Transcription
Metabolites
Circadian Rhythm
DNA Replication
Metabolism
Gene expression
NAD

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

これを引用

The circadian clock transcriptional complex : Metabolic feedback intersects with epigenetic control. / Masri, Selma; Zocchi, Loredana; Katada, Sayako; Mora, Eugenio; Sassone-Corsi, Paolo.

:: Annals of the New York Academy of Sciences, 巻 1264, 番号 1, 08.2012, p. 103-109.

研究成果: ジャーナルへの寄稿記事

Masri, Selma ; Zocchi, Loredana ; Katada, Sayako ; Mora, Eugenio ; Sassone-Corsi, Paolo. / The circadian clock transcriptional complex : Metabolic feedback intersects with epigenetic control. :: Annals of the New York Academy of Sciences. 2012 ; 巻 1264, 番号 1. pp. 103-109.
@article{1f8290fdf1284cd9b3e9f0a9c6a31e0a,
title = "The circadian clock transcriptional complex: Metabolic feedback intersects with epigenetic control",
abstract = "Chromatin remodeling is a prerequisite for most nuclear functions, including transcription, silencing, and DNA replication. Accumulating evidence shows that many physiological processes require highly sophisticated events of chromatin remodeling. Recent findings have linked cellular metabolism, epigenetic state, and the circadian clock. The control of a large variety of neuronal, behavioral, and physiological responses follows diurnal rhythms. This is possible through a transcriptional regulatory network that governs a significant portion of the genome. The harmonic oscillation of gene expression is paralleled by critical events of chromatin remodeling that appear to provide specificity and plasticity in circadian regulation. Accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes. These notions indicate that the circadian epigenome might integrate tissue specificity within biological pacemakers, bridging systems physiology to metabolic control. This review highlights several advances related to the circadian epigenome, the contribution of NAD+ as a critical signaling metabolite, and its effects on epigenetic state, followed by more recent reports on circadian metabolomics analyses.",
author = "Selma Masri and Loredana Zocchi and Sayako Katada and Eugenio Mora and Paolo Sassone-Corsi",
year = "2012",
month = "8",
doi = "10.1111/j.1749-6632.2012.06649.x",
language = "English",
volume = "1264",
pages = "103--109",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The circadian clock transcriptional complex

T2 - Metabolic feedback intersects with epigenetic control

AU - Masri, Selma

AU - Zocchi, Loredana

AU - Katada, Sayako

AU - Mora, Eugenio

AU - Sassone-Corsi, Paolo

PY - 2012/8

Y1 - 2012/8

N2 - Chromatin remodeling is a prerequisite for most nuclear functions, including transcription, silencing, and DNA replication. Accumulating evidence shows that many physiological processes require highly sophisticated events of chromatin remodeling. Recent findings have linked cellular metabolism, epigenetic state, and the circadian clock. The control of a large variety of neuronal, behavioral, and physiological responses follows diurnal rhythms. This is possible through a transcriptional regulatory network that governs a significant portion of the genome. The harmonic oscillation of gene expression is paralleled by critical events of chromatin remodeling that appear to provide specificity and plasticity in circadian regulation. Accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes. These notions indicate that the circadian epigenome might integrate tissue specificity within biological pacemakers, bridging systems physiology to metabolic control. This review highlights several advances related to the circadian epigenome, the contribution of NAD+ as a critical signaling metabolite, and its effects on epigenetic state, followed by more recent reports on circadian metabolomics analyses.

AB - Chromatin remodeling is a prerequisite for most nuclear functions, including transcription, silencing, and DNA replication. Accumulating evidence shows that many physiological processes require highly sophisticated events of chromatin remodeling. Recent findings have linked cellular metabolism, epigenetic state, and the circadian clock. The control of a large variety of neuronal, behavioral, and physiological responses follows diurnal rhythms. This is possible through a transcriptional regulatory network that governs a significant portion of the genome. The harmonic oscillation of gene expression is paralleled by critical events of chromatin remodeling that appear to provide specificity and plasticity in circadian regulation. Accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes. These notions indicate that the circadian epigenome might integrate tissue specificity within biological pacemakers, bridging systems physiology to metabolic control. This review highlights several advances related to the circadian epigenome, the contribution of NAD+ as a critical signaling metabolite, and its effects on epigenetic state, followed by more recent reports on circadian metabolomics analyses.

UR - http://www.scopus.com/inward/record.url?scp=84864857778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864857778&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2012.06649.x

DO - 10.1111/j.1749-6632.2012.06649.x

M3 - Article

C2 - 22834651

AN - SCOPUS:84864857778

VL - 1264

SP - 103

EP - 109

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

IS - 1

ER -