The circadian clock transcriptional complex: Metabolic feedback intersects with epigenetic control

Selma Masri, Loredana Zocchi, Sayako Katada, Eugenio Mora, Paolo Sassone-Corsi

研究成果: Contribution to journalArticle査読

42 被引用数 (Scopus)

抄録

Chromatin remodeling is a prerequisite for most nuclear functions, including transcription, silencing, and DNA replication. Accumulating evidence shows that many physiological processes require highly sophisticated events of chromatin remodeling. Recent findings have linked cellular metabolism, epigenetic state, and the circadian clock. The control of a large variety of neuronal, behavioral, and physiological responses follows diurnal rhythms. This is possible through a transcriptional regulatory network that governs a significant portion of the genome. The harmonic oscillation of gene expression is paralleled by critical events of chromatin remodeling that appear to provide specificity and plasticity in circadian regulation. Accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes. These notions indicate that the circadian epigenome might integrate tissue specificity within biological pacemakers, bridging systems physiology to metabolic control. This review highlights several advances related to the circadian epigenome, the contribution of NAD+ as a critical signaling metabolite, and its effects on epigenetic state, followed by more recent reports on circadian metabolomics analyses.

本文言語英語
ページ(範囲)103-109
ページ数7
ジャーナルAnnals of the New York Academy of Sciences
1264
1
DOI
出版ステータス出版済み - 8 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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