TY - JOUR
T1 - The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation
AU - Zhang, Lumin
AU - Si, Xiaojia
AU - Yang, Yangyang
AU - Zimmer, Marc
AU - Witzel, Sina
AU - Sekine, Kohei
AU - Rudolph, Matthias
AU - Hashmi, A. Stephen K.
N1 - Funding Information:
L.Z., X.S., and Y.Y. are grateful for PhD fellowships from the China Scholarship Council (CSC). S.W. acknowledges the support by the Landesgraduiertenfçrderung of the state of Baden-Württemberg, Germany.
Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/2/4
Y1 - 2019/2/4
N2 - Herein we report a highly selective photoredox C(sp 3 )−H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp 3 )−H alkylation/arylation of ethers. A selective late-stage modification of (−)-ambroxide has also been conducted to demonstrate the applicability of the method.
AB - Herein we report a highly selective photoredox C(sp 3 )−H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp 3 )−H alkylation/arylation of ethers. A selective late-stage modification of (−)-ambroxide has also been conducted to demonstrate the applicability of the method.
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U2 - 10.1002/anie.201810526
DO - 10.1002/anie.201810526
M3 - Article
C2 - 30417501
AN - SCOPUS:85059700656
SN - 1433-7851
VL - 58
SP - 1823
EP - 1827
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 6
ER -