The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery

A. Tsuchiya, T. Mori, Y. Naritomi, J. H. Kang, D. Asai, T. Niidome, Y. Endo, R. Suzuki, Y. Negishi, K. Maruyama, Y. Katayama

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

We have developed new gene expression-regulating polymer that can activate transgene expression in response to target intracellular signals. Here, we tried applying sonoporation system to this gene regulation system to enhance the gene expression efficacy. Sonoporation is the method for effective gene transfection in vitro and in vivo. Therefore, the method might enhance the transfection efficiency in our polymer and realize an efficient and safe gene delivery system. Results suggested that the combination of our polymer and sonoporation could improve the gene expression compared to the system using only our polymer that transfers genes into cells via endocytosis. It also kept the ability of the gene regulation responding to cellular signals.

本文言語英語
ホスト出版物のタイトルNanobiotechnology and Nanobiophotonics - Opportunities and Challenges
ページ7-11
ページ数5
出版ステータス出版済み - 12月 1 2010
イベント2009 MRS Fall Meeting - Boston, MA, 米国
継続期間: 11月 29 200912月 3 2009

出版物シリーズ

名前Materials Research Society Symposium Proceedings
1237
ISSN(印刷版)0272-9172

会議

会議2009 MRS Fall Meeting
国/地域米国
CityBoston, MA
Period11/29/0912/3/09

!!!All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 凝縮系物理学
  • 材料力学
  • 機械工学

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