The combination of green tea extract and eriodictyol inhibited high-fat/high-sucrose diet-induced cholesterol upregulation is accompanied by suppression of cholesterol synthesis enzymes

Mai Yamashita, Motofumi Kumazoe, Yuki Nakamura, Yeong Seon Won, Jaehoon Bae, Shuya Yamashita, Hirofumi Tachibana

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

Western diets induce obesity associated with an increased risk of hypercholesterolaemia. Indeed, obesity-induced hypercholesterolaemia is correlated with increased coronary cardiovascular disease (CVD) risk. Male C57BL/6J mice were fed a normal diet, highfat and high-sucrose diet (HF/HS), HF/HS with green tea extract powder diet (HF/HS1GT), HF/HS with eriodictyol diet (HF/HS1Eri), or HF/HS with green tea extract powder and eriodictyol diet (HF/HS1GT1Eri) for 8 wk. Body weight was lower in the HF/HS1GT1Eri group than in the HF/HS group (-8.3%, p <0.01). The HF/HS diet elicited an upregulation of total cholesterol levels (-63%, p <0.001), and low-density lipoprotein (LDL) levels (-89%, p <0.001) were significantly suppressed by the GT1Eri diet. Conversely, no change (p>0.05) was observed in the HF/HS1GT and HF/HS1Eri groups. The HF/HS diet-induced hepatic mRNA increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) was ameliorated (-73%) by the oral administration of green tea extract and eriodictyol. Moreover, the GT1Eri diet suppressed HF/HS diet-induced upregulation of 3-hydroxy-3-methylglutaryl- coenzyme A synthase (HMGCS) (275%, p <0.05). Furthermore, the LDL receptor (LDLR) levels were higher in the HF/HS1GT1Eri group (+150%, p <0.05) than in the HF/ HS group. These results suggest that a combination of green tea and eriodictyol decreases cholesterol levels, particularly LDL levels, accompanied by the suppression of HMGCR and HMGCS levels and upregulation of LDLR levels in the liver.

本文言語英語
ページ(範囲)249-256
ページ数8
ジャーナルJournal of Nutritional Science and Vitaminology
62
4
DOI
出版ステータス出版済み - 2016

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 栄養および糖尿病

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