[The concept and history of biomarker].

Ryoji Nonaka, Junichi Nishimura, Masaki Mori

研究成果: Contribution to journalReview article査読

抄録

Biomarker is a characteristic objectively measured and an indicator of biological process. This term indicates not only biological substance, for example protein, ribonucleic acid but also imaging assays. Disease biomarkers have been applied to a wide variety of clinical areas, including oncology, metabolic disorders, neurological disease and immune dysregulation. In recent years because of the progress of analysis technology, new biomarkers continue to be devised and used as diagnostic, predictive, prognostic, and toxic marker. In drug development area, biomarkers are used as surrogate endpoint to substitute for a clinical endpoint and needed for rational drug development. Here, we summarize the concept and history of biomarker.

本文言語英語
ページ(範囲)737-742
ページ数6
ジャーナルNihon rinsho. Japanese journal of clinical medicine
70
5
出版ステータス出版済み - 5 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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