The crystal structure of novel chondroitin lyase ODV-E66, a baculovirus envelope protein

Yoshirou Kawaguchi, Nobuo Sugiura, Koji Kimata, Makoto Kimura, Yoshimitsu Kakuta

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Chondroitin lyases have been known as pathogenic bacterial enzymes that degrade chondroitin. Recently, baculovirus envelope protein ODV-E66 was identified as the first reported viral chondroitin lyase. ODV-E66 has low sequence identity with bacterial lyases at <12%, and unique characteristics reflecting the life cycle of baculovirus. To understand ODV-E66's structural basis, the crystal structure was determined and it was found that the structural fold resembled that of polysaccharide lyase 8 proteins and that the catalytic residues were also conserved. This structure enabled discussion of the unique substrate specificity and the stability of ODV-E66 as well as the host specificity of baculovirus.

元の言語英語
ページ(範囲)3943-3948
ページ数6
ジャーナルFEBS Letters
587
発行部数24
DOI
出版物ステータス出版済み - 12 11 2013

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Chondroitin Lyases
Baculoviridae
Polysaccharide-Lyases
Crystal structure
Chondroitin
Lyases
Life cycle
Proteins
Host Specificity
Substrate Specificity
Life Cycle Stages
Substrates
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

これを引用

The crystal structure of novel chondroitin lyase ODV-E66, a baculovirus envelope protein. / Kawaguchi, Yoshirou; Sugiura, Nobuo; Kimata, Koji; Kimura, Makoto; Kakuta, Yoshimitsu.

:: FEBS Letters, 巻 587, 番号 24, 11.12.2013, p. 3943-3948.

研究成果: ジャーナルへの寄稿記事

Kawaguchi, Yoshirou ; Sugiura, Nobuo ; Kimata, Koji ; Kimura, Makoto ; Kakuta, Yoshimitsu. / The crystal structure of novel chondroitin lyase ODV-E66, a baculovirus envelope protein. :: FEBS Letters. 2013 ; 巻 587, 番号 24. pp. 3943-3948.
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