TY - JOUR
T1 - The differential coupling of oxytocin receptors to uterine contractions in murine estrous cycle
AU - Kawamata, Masaki
AU - Tonomura, Yutaka
AU - Kimura, Tadashi
AU - Yanagisawa, Teruyuki
AU - Nishimori, Katsuhiko
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research (No. 14360126) from the Ministry of Education, Science and Culture of Japan and by Sankyo Foundation of Life Science.
PY - 2004/8/27
Y1 - 2004/8/27
N2 - Oxytocin (OT)-induced uterine contractility in different ovulatory phases has not been characterized in mouse. While the uterus was refractory to OT at diestrous phase, numerous contractions were observed at estrous phase. The magnitude of uterine contractile response to OT at estrous phase was larger than that at diestrous phase. There was also significant difference in the pD 2 values for OT between the samples from the two phases. However, the level of OT receptor (OTR) transcripts and proteins was equivalent at the two phases. These results suggest that OT-induced uterine contraction is not only regulated by the quantity of OTR in the non-pregnant mouse uterus.
AB - Oxytocin (OT)-induced uterine contractility in different ovulatory phases has not been characterized in mouse. While the uterus was refractory to OT at diestrous phase, numerous contractions were observed at estrous phase. The magnitude of uterine contractile response to OT at estrous phase was larger than that at diestrous phase. There was also significant difference in the pD 2 values for OT between the samples from the two phases. However, the level of OT receptor (OTR) transcripts and proteins was equivalent at the two phases. These results suggest that OT-induced uterine contraction is not only regulated by the quantity of OTR in the non-pregnant mouse uterus.
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U2 - 10.1016/j.bbrc.2004.07.019
DO - 10.1016/j.bbrc.2004.07.019
M3 - Article
C2 - 15358162
AN - SCOPUS:4344612892
VL - 321
SP - 695
EP - 699
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -