The differential coupling of oxytocin receptors to uterine contractions in murine estrous cycle

Masaki Kawamata, Yutaka Tonomura, Tadashi Kimura, Teruyuki Yanagisawa, Katsuhiko Nishimori

研究成果: ジャーナルへの寄稿学術誌査読

9 被引用数 (Scopus)

抄録

Oxytocin (OT)-induced uterine contractility in different ovulatory phases has not been characterized in mouse. While the uterus was refractory to OT at diestrous phase, numerous contractions were observed at estrous phase. The magnitude of uterine contractile response to OT at estrous phase was larger than that at diestrous phase. There was also significant difference in the pD 2 values for OT between the samples from the two phases. However, the level of OT receptor (OTR) transcripts and proteins was equivalent at the two phases. These results suggest that OT-induced uterine contraction is not only regulated by the quantity of OTR in the non-pregnant mouse uterus.

本文言語英語
ページ(範囲)695-699
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
321
3
DOI
出版ステータス出版済み - 8月 27 2004
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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