The effect of Clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis

Asuka Yasueda, Tsunekazu Mizushima, Riichiro Nezu, Ryoko Sumi, Mamoru Tanaka, Junichi Nishimura, Yasuyuki Kai, Masaki Hirota, Hideki Osawa, Kiyokazu Nakajima, Masaki Mori, Toshinori Ito

研究成果: Contribution to journalArticle査読

56 被引用数 (Scopus)

抄録

Purpose: Ulcerative colitis (UC) is a chronic, relapsing, and refractory disorder of the intestine. Total proctocolectomy with ileal pouch anal anastomosis (IPAA) is the preferred and standard surgical procedure for patients’ refractory to medical therapy. Pouchitis is one of the most common long-term complications after IPAA. In the present study, the safety and efficacy of Clostridium butyricum MIYAIRI (CBM) as a probiotic were examined. Methods: A randomized and placebo-controlled study was performed. Seventeen patients were recruited from 2007 to 2013. Nine tablets of MIYA-BM® or placebo were orally administered once daily. The cumulative pouchitis-free survival, pouch condition (using the modified pouch disease activity index), and blood parameters were evaluated. A fecal sample analysis was also performed. Results: Subjects were randomly allocated to receive MIYA-BM or placebo (9 and 8 subjects, respectively). One subject in the MIYA-BM group and four subjects in the placebo group developed pouchitis. No side effects occurred in either group. Characteristic intestinal flora was observed in each group. Conclusions: Our results suggest that probiotic therapy with CBM achieved favorable results with minimal side effects and might be a useful complementary therapy for the prevention of pouchitis in patients with UC who have undergone IPAA.

本文言語英語
ページ(範囲)939-949
ページ数11
ジャーナルSurgery today
46
8
DOI
出版ステータス出版済み - 8 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科

フィンガープリント

「The effect of Clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル