[The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs].

Tomoki Takeda, Junki Taura, Misaki Fujii, Takayuki Koga, Yuji Ishii, Hideyuki Yamada

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposed to pregnant or lactational mother impairs the reproduction and development of the pups. The defect is a serious problem, because it is caused by TCDD at much lower doses than that needed for acute toxicity in the mother. However, the toxic mechanism underlying the defect remains to be obscure. We have previously revealed that maternal exposure to TCDD (1 microg/kg) causes a reduction in luteinizing hormone in the fetal pituitary, leading to the reduced expression of testicular steroidogenic proteins such as steroidogenic acute-regulatory protein (StAR) and cytochrome P450 (CYP) 17. In addition, we have provided evidence that such a reduction imprints defects in sexual behaviors at adulthood. In this study, we investigated TCDD effect on fetal steroidogenesis in the extra-gonadal tissues. Even when pregnant Wistar rats at gestational day (GD) 15 were orally treated with TCDD (0.25, 1 or 3 microg/kg), neither expression of StAR nor CYP17 mRNA was affected in the adrenal gland, placenta and hypothalamus of male fetuses (GD20). However, TCDD induced placental StAR (3 microg/kg) and adrenal CYP17 mRNAs (0.25 microg/kg) in female fetuses. Therefore, our study suggests that while TCDD gives damage to male fetal steroidogenesis in a testis-specific manner, the dioxin enhances the steroidogenesis of the fetal adrenal gland and placenta in females. Thus, the mechanism whereby TCDD exerts its endocrine-disrupting properties is considered to differ, at least partially, between male and female fetuses.

元の言語英語
ページ(範囲)159-166
ページ数8
ジャーナルFukuoka Acta Medica
102
発行部数4
出版物ステータス出版済み - 4 2011

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Maternal Exposure
Dioxins
Steroid 17-alpha-Hydroxylase
Fetus
Adrenal Glands
Placenta
Messenger RNA
Polychlorinated Dibenzodioxins
Poisons
Luteinizing Hormone
Sexual Behavior
Cytochrome P-450 Enzyme System
Hypothalamus
Reproduction
Testis
Wistar Rats

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Takeda, T., Taura, J., Fujii, M., Koga, T., Ishii, Y., & Yamada, H. (2011). [The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs]. Fukuoka Acta Medica, 102(4), 159-166.

[The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs]. / Takeda, Tomoki; Taura, Junki; Fujii, Misaki; Koga, Takayuki; Ishii, Yuji; Yamada, Hideyuki.

:: Fukuoka Acta Medica, 巻 102, 番号 4, 04.2011, p. 159-166.

研究成果: ジャーナルへの寄稿記事

Takeda, T, Taura, J, Fujii, M, Koga, T, Ishii, Y & Yamada, H 2011, '[The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs].', Fukuoka Acta Medica, 巻. 102, 番号 4, pp. 159-166.
Takeda, Tomoki ; Taura, Junki ; Fujii, Misaki ; Koga, Takayuki ; Ishii, Yuji ; Yamada, Hideyuki. / [The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs]. :: Fukuoka Acta Medica. 2011 ; 巻 102, 番号 4. pp. 159-166.
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