抄録
The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a wholecell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At -50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | S53-S56 |
| ジャーナル | European Archives of Oto-Rhino-Laryngology |
| 巻 | 251 |
| 号 | 1 Supplement |
| DOI | |
| 出版ステータス | 出版済み - 8月 1 1994 |
!!!All Science Journal Classification (ASJC) codes
- 耳鼻咽喉科学