The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells

T. Kimitsuki, T. Nakagawa, K. Hisashi, S. Komune, T. Uemura

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The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a wholecell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At -50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.

元の言語英語
ページ(範囲)S53-S56
ジャーナルEuropean Archives of Oto-Rhino-Laryngology
251
発行部数1 Supplement
DOI
出版物ステータス出版済み - 8 1 1994

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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