抜粋
The effects of ototoxic drugs on mechano-electrical transduction (MET) currents were investigated in dissociated cochlear hair cells of the chick, using a wholecell patch-electrode voltage-clamp technique. Dihydrostreptomycin (DHSM) and cisplatin (cis-dichlorodiammine platinum II, CDDP) blocked the MET channel in a dose- and voltage-dependent manner. In contrast, acetyl salicylate did not suppress the MET current. At -50 mV, DHSM and CDDP blocked the MET channel with a Hill coefficient of 0.93 and 2.1, respectively. These findings suggest that a single DHSM molecule or more than one CDDP molecule binds to a single MET channel.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | S53-S56 |
| ジャーナル | European Archives of Oto-Rhino-Laryngology |
| 巻 | 251 |
| 発行部数 | 1 Supplement |
| DOI | |
| 出版物ステータス | 出版済み - 8 1 1994 |
All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
フィンガープリント The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Kimitsuki, T., Nakagawa, T., Hisashi, K., Komune, S., & Uemura, T. (1994). The effects of ototoxic drugs on mechano-electric transduction channels in chick cochlear hair cells. European Archives of Oto-Rhino-Laryngology, 251(1 Supplement), S53-S56. https://doi.org/10.1007/BF02565220