The efficacy of adjuvant immunochemotherapy with OK-432 after curative resection of gastric cancer: an individual patient data meta-analysis of randomized controlled trials

Mari S. Oba, Satoshi Teramukai, Yasuo Ohashi, Kenji Ogawa, Yoshihiko Maehara, Junichi Sakamoto

研究成果: ジャーナルへの寄稿学術誌査読

13 被引用数 (Scopus)

抄録

Background: OK-432 has been used as a cancer treatment for 40 years, and the immunostimulatory effects of OK-432 therapy have been intensely investigated in Japan. Recently, it has received attention as a possible booster for cancer vaccine treatments. Our previous meta-analysis based on summary measures revealed a significant improvement in the survival of patients with curatively resected gastric cancer. However, it is impossible to exclude the possibility of bias due to several prognostic factors. Methods: We collected individual data for patients with stage III or stage IV gastric cancer after curative resection from 14 trials that were identified in a previous meta-analysis. Immunochemotherapy with OK-432 was compared with treatment with standard chemotherapy on an intention-to-treat basis. The primary end point was overall survival. Stratified survival analyses were performed with the trial as the stratification factor. Subgroup analyses were also performed according to the potential prognostic factors, which included pathological factors, splenectomy, and delayed-type hypersensitivity. Results: There were 796 and 726 patients in the OK-432 and control groups, respectively. The median overall survival was 42.6 months for the OK-432 group and 32.3 months for the control group. The overall hazard ratio was 0.88 (95 % confidence interval 0.77–1.00, p = 0.050). No factor showed a statistically significant interaction in the subgroup analyses. Conclusions: The results suggest that immunochemotherapy treatment with OK-432 could have a borderline significant effect for patients with stage III or stage IV gastric cancer after curative resection.

本文言語英語
ページ(範囲)616-624
ページ数9
ジャーナルGastric Cancer
19
2
DOI
出版ステータス出版済み - 4月 1 2016

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 消化器病学
  • 癌研究

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