The Evolution of Complement System Functions and Pathways in Vertebrates

研究成果: 著書/レポートタイプへの貢献

2 引用 (Scopus)

抄録

An evolutionarily ancestral complement system is considered to be an opsonic system that seems to be a combination of the lectin and alternative pathways known in mammalian complement. The ancestral system is equipped with lectin-like pattern-recognition molecules linked with specific proteases homologous to the mannose-binding lectin-associated serine protease (MASP) and factor B, which cleave C3 into physiologically active forms with inflammatory and opsonic functions, as seen in primitive invertebrate species. In vertebrates, two rounds of whole-genome duplication allowed the occurrence of two additional reaction cascades, the classical and lytic pathways, providing jawed vertebrates with much more specific and efficient ability of pathogen elimination. A trace of molecular and functional evidence that represents a transient status from invertebrate prototypic complement to a full equipped system can be found in extant jawless species such as lamprey. A striking diversity of complement component isoforms unique to teleost fish is also discussed in evolutionary and functional points of view.

元の言語英語
ホスト出版物のタイトルThe Evolution of the Immune System
ホスト出版物のサブタイトルConservation and Diversification
出版者Elsevier Inc.
ページ151-171
ページ数21
ISBN(電子版)9780128020135
ISBN(印刷物)9780128019757
DOI
出版物ステータス出版済み - 5 20 2016

Fingerprint

Invertebrates
Lectins
Vertebrates
Mannose-Binding Lectin
Lampreys
Serine Proteases
Protein Isoforms
Fishes
Peptide Hydrolases
Genome

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)

これを引用

Nakao, M., & Somamoto, T. (2016). The Evolution of Complement System Functions and Pathways in Vertebrates. : The Evolution of the Immune System: Conservation and Diversification (pp. 151-171). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801975-7.00006-2

The Evolution of Complement System Functions and Pathways in Vertebrates. / Nakao, Miki; Somamoto, Tomonori.

The Evolution of the Immune System: Conservation and Diversification. Elsevier Inc., 2016. p. 151-171.

研究成果: 著書/レポートタイプへの貢献

Nakao, M & Somamoto, T 2016, The Evolution of Complement System Functions and Pathways in Vertebrates. : The Evolution of the Immune System: Conservation and Diversification. Elsevier Inc., pp. 151-171. https://doi.org/10.1016/B978-0-12-801975-7.00006-2
Nakao M, Somamoto T. The Evolution of Complement System Functions and Pathways in Vertebrates. : The Evolution of the Immune System: Conservation and Diversification. Elsevier Inc. 2016. p. 151-171 https://doi.org/10.1016/B978-0-12-801975-7.00006-2
Nakao, Miki ; Somamoto, Tomonori. / The Evolution of Complement System Functions and Pathways in Vertebrates. The Evolution of the Immune System: Conservation and Diversification. Elsevier Inc., 2016. pp. 151-171
@inbook{4b5cd07bd9c8477c9be001a6245b4080,
title = "The Evolution of Complement System Functions and Pathways in Vertebrates",
abstract = "An evolutionarily ancestral complement system is considered to be an opsonic system that seems to be a combination of the lectin and alternative pathways known in mammalian complement. The ancestral system is equipped with lectin-like pattern-recognition molecules linked with specific proteases homologous to the mannose-binding lectin-associated serine protease (MASP) and factor B, which cleave C3 into physiologically active forms with inflammatory and opsonic functions, as seen in primitive invertebrate species. In vertebrates, two rounds of whole-genome duplication allowed the occurrence of two additional reaction cascades, the classical and lytic pathways, providing jawed vertebrates with much more specific and efficient ability of pathogen elimination. A trace of molecular and functional evidence that represents a transient status from invertebrate prototypic complement to a full equipped system can be found in extant jawless species such as lamprey. A striking diversity of complement component isoforms unique to teleost fish is also discussed in evolutionary and functional points of view.",
author = "Miki Nakao and Tomonori Somamoto",
year = "2016",
month = "5",
day = "20",
doi = "10.1016/B978-0-12-801975-7.00006-2",
language = "English",
isbn = "9780128019757",
pages = "151--171",
booktitle = "The Evolution of the Immune System",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - The Evolution of Complement System Functions and Pathways in Vertebrates

AU - Nakao, Miki

AU - Somamoto, Tomonori

PY - 2016/5/20

Y1 - 2016/5/20

N2 - An evolutionarily ancestral complement system is considered to be an opsonic system that seems to be a combination of the lectin and alternative pathways known in mammalian complement. The ancestral system is equipped with lectin-like pattern-recognition molecules linked with specific proteases homologous to the mannose-binding lectin-associated serine protease (MASP) and factor B, which cleave C3 into physiologically active forms with inflammatory and opsonic functions, as seen in primitive invertebrate species. In vertebrates, two rounds of whole-genome duplication allowed the occurrence of two additional reaction cascades, the classical and lytic pathways, providing jawed vertebrates with much more specific and efficient ability of pathogen elimination. A trace of molecular and functional evidence that represents a transient status from invertebrate prototypic complement to a full equipped system can be found in extant jawless species such as lamprey. A striking diversity of complement component isoforms unique to teleost fish is also discussed in evolutionary and functional points of view.

AB - An evolutionarily ancestral complement system is considered to be an opsonic system that seems to be a combination of the lectin and alternative pathways known in mammalian complement. The ancestral system is equipped with lectin-like pattern-recognition molecules linked with specific proteases homologous to the mannose-binding lectin-associated serine protease (MASP) and factor B, which cleave C3 into physiologically active forms with inflammatory and opsonic functions, as seen in primitive invertebrate species. In vertebrates, two rounds of whole-genome duplication allowed the occurrence of two additional reaction cascades, the classical and lytic pathways, providing jawed vertebrates with much more specific and efficient ability of pathogen elimination. A trace of molecular and functional evidence that represents a transient status from invertebrate prototypic complement to a full equipped system can be found in extant jawless species such as lamprey. A striking diversity of complement component isoforms unique to teleost fish is also discussed in evolutionary and functional points of view.

UR - http://www.scopus.com/inward/record.url?scp=84987747994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84987747994&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-801975-7.00006-2

DO - 10.1016/B978-0-12-801975-7.00006-2

M3 - Chapter

AN - SCOPUS:84987747994

SN - 9780128019757

SP - 151

EP - 171

BT - The Evolution of the Immune System

PB - Elsevier Inc.

ER -