The expression level of pd-l1 (CD274) mrna in peripheral blood is a potential biomarker for predicting recurrence in breast cancer

Takaaki Masuda, Miwa Noda, Akihiro Kitagawa, Qingjiang Hu, Atsushi Fujii, Shuhei Ito, Keisuke Kosai, Yuki Ando, Yoshihiro Matsumoto, hajime otsu, Hiroki Uchida, Shinji Ohno, Koshi Mimori

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Background/Aim: Programmed death-ligand 1 (PD-L1/CD274) elicits T-cell anergy, leading to immune suppression. We aimed to determine the prognostic relevance of PD-L1 expression in the blood of breast cancer (BC) patients. Materials and Methods: We measured PD-L1 mRNA expression in blood and tumor tissues of BC patients using RT-qPCR and a dataset from The Cancer Genome Atlas, and performed a survival analysis of PD-L1 expression in the blood of 330 BC patients. Flow cytometric analysis was performed using blood cells. Results: No statistical difference in PD-L1 expression was seen between normal controls and BC in blood or tissues. There was a significant positive correlation between the PD-L1 expression levels in blood and tissues. Decreased PD-L1 expression in blood or tissues was associated with poor recurrence-free survival. PD-L1 is mainly expressed in polymorphonuclear leukocytes. Conclusion: Low expression of PD-L1 in the blood could serve as a biomarker of poor prognosis in BC patients.

本文言語英語
ページ(範囲)3733-3742
ページ数10
ジャーナルAnticancer research
40
7
DOI
出版ステータス出版済み - 7 2020

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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