The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line

Minoru Takata, Masamichi Ishiai, Hiroyuki Kitao

研究成果: Contribution to journalReview article

11 引用 (Scopus)

抜粋

The Fanconi anemia (FA) pathway is a complex phosphorylation-ubiquitination network in the DNA damage signaling, which is still poorly understood. Defects in the "FA pathway" or in the related DNA repair proteins cause FA, a hereditary disorder that accompanies compromised DNA crosslink repair, poor hematopoetic stem cell survival, genomic instability, and cancer. For molecular dissection of the FA pathway, we have been using chicken B cell line DT40 as a model system. In this review, we will summarize our current understanding of the pathway, and discuss how studies using DT40 have contributed to this rapidly evolving field.

元の言語英語
ページ(範囲)92-102
ページ数11
ジャーナルMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
668
発行部数1-2
DOI
出版物ステータス出版済み - 7 31 2009
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

フィンガープリント The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用