The first asymmetric epoxidation using a combination of achiral (salen)manganese(III) complex and chiral amine

Takashi Hashihayata, Yoshio Ito, Tsutomu Katsuki

研究成果: Contribution to journalArticle査読

96 被引用数 (Scopus)

抄録

A new catalyst system for asymmetric epoxidation was developed by using an achiral (salen)manganese(III) complex with chiral amine. Commercially available (-)-sparteine showed the highest asymmetric induction over the other chiral amines examined and addition of water to the reaction medium improved the induction up to 73% ee in the epoxidation of chromene derivative. Application of the system to the asymmetric oxidation of methyl phenyl sulfide to its sulfoxide was a so examined (at most 25% ee). These results support our proposal that a non-planar and chiral structure of the salen ligand plays an important role in the enantioface selection of olefins by (salen)manganese(III) complex.

本文言語英語
ページ(範囲)9541-9552
ページ数12
ジャーナルTetrahedron
53
28
DOI
出版ステータス出版済み - 7 14 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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