The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

Gerald Siu, Stephen P. Clark, Yasunobu Yoshikai, Marie Malissen, Yusuke Yanagi, Erich Strauss, Tak W. Mak, Leroy Hood

    研究成果: ジャーナルへの寄稿記事

    178 引用 (Scopus)

    抄録

    A cDNA clone YT35, synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes. We have isolated and sequenced the germ-line V and J gene segment counterparts to YT35 from a human cosmid library, and these failed to encode 14 nucleotides of the cDNA clone between the V and J regions. We postulate that these 14 nucleotides are encoded by a third gene segment analogous to the diversity (D) gene segments of immunoglobulin heavy chain genes. This T cell antigen receptor V gene appears to be assembled from three gene segments, V, D, and J, and accordingly most closely resembles immunoglobulin heavy chain V genes.

    元の言語英語
    ページ(範囲)393-401
    ページ数9
    ジャーナルCell
    37
    発行部数2
    DOI
    出版物ステータス出版済み - 1 1 1984

    Fingerprint

    Antigen Receptors
    Joining
    Genes
    Immunoglobulin Heavy Chain Genes
    Immunoglobulin Heavy Chains
    Nucleotides
    Complementary DNA
    Clone Cells
    Cosmids
    Immunoglobulin Genes
    T-Cell Antigen Receptor
    Germ Cells
    T-cells
    T-Lymphocytes
    Messenger RNA
    Immunoglobulins
    Tumors
    Neoplasms

    All Science Journal Classification (ASJC) codes

    • Biochemistry, Genetics and Molecular Biology(all)

    これを引用

    The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. / Siu, Gerald; Clark, Stephen P.; Yoshikai, Yasunobu; Malissen, Marie; Yanagi, Yusuke; Strauss, Erich; Mak, Tak W.; Hood, Leroy.

    :: Cell, 巻 37, 番号 2, 01.01.1984, p. 393-401.

    研究成果: ジャーナルへの寄稿記事

    Siu, Gerald ; Clark, Stephen P. ; Yoshikai, Yasunobu ; Malissen, Marie ; Yanagi, Yusuke ; Strauss, Erich ; Mak, Tak W. ; Hood, Leroy. / The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. :: Cell. 1984 ; 巻 37, 番号 2. pp. 393-401.
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    abstract = "A cDNA clone YT35, synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes. We have isolated and sequenced the germ-line V and J gene segment counterparts to YT35 from a human cosmid library, and these failed to encode 14 nucleotides of the cDNA clone between the V and J regions. We postulate that these 14 nucleotides are encoded by a third gene segment analogous to the diversity (D) gene segments of immunoglobulin heavy chain genes. This T cell antigen receptor V gene appears to be assembled from three gene segments, V, D, and J, and accordingly most closely resembles immunoglobulin heavy chain V genes.",
    author = "Gerald Siu and Clark, {Stephen P.} and Yasunobu Yoshikai and Marie Malissen and Yusuke Yanagi and Erich Strauss and Mak, {Tak W.} and Leroy Hood",
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    AU - Siu, Gerald

    AU - Clark, Stephen P.

    AU - Yoshikai, Yasunobu

    AU - Malissen, Marie

    AU - Yanagi, Yusuke

    AU - Strauss, Erich

    AU - Mak, Tak W.

    AU - Hood, Leroy

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