The IL-13–OVOL1–FLG axis in atopic dermatitis

Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Dugarmaa Ulzii, Yen Hai Vu, Makiko Kido-Nakahara, Takeshi Nakahara, Masutaka Furue

研究成果: Contribution to journalReview article査読

17 被引用数 (Scopus)

抄録

Despite sharing interleukin-4 receptor α (IL-4Rα) in their signaling cascades, IL-4 and IL-13 have different functions in atopic inflammation. IL-13 preferentially participates in the peripheral tissues because tissue-resident group 2 innate lymphoid cells produce IL-13 but not IL-4. In contrast, lymph node T follicular helper cells express IL-4 but not IL-13 to regulate B-cell immunity. The dominant microenvironment of IL-13 is evident in the lesional skin of atopic dermatitis (AD). The IL-13-rich local milieu causes barrier dysfunction by down-regulating the OVOL1–filaggrin (FLG) axis and up-regulating the periostin–IL-24 axis. Genome-wide association studies also point to the crucial involvement of the IL-13, OVOL1 and FLG genes in the pathogenesis of AD. Biologics targeting IL-13, such as the anti-IL-4Rα antibody dupilumab and the anti-IL-13 antibody tralokinumab, successfully improve AD lesions and further highlight the importance of IL-13 in the pathogenesis of AD.

本文言語英語
ページ(範囲)281-286
ページ数6
ジャーナルImmunology
158
4
DOI
出版ステータス出版済み - 12 1 2019

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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