The impact of taurine-and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: Antidepressant versus anxiolytic-like effects

Tatsuro Murakami, Mitsuhiro Furuse

研究成果: ジャーナルへの寄稿学術誌査読

63 被引用数 (Scopus)

抄録

Taurine, a substrate of taurine transporter, has functions as a neuromodulator and antioxidant and betaalanine, a taurine transporter inhibitor, has a role as a neurotransmitter in the brain, and they were expected to be involved in depression-like behavior and antidepressant treatment. These facts aroused our interest in new capabilities of taurine and beta-alanine. Thus, to investigate the effects of chronic ingestion of taurine-(22.5 mmol/kg diet) supplemented diet and beta-alanine-(22.5 mmol/kg diet) supplemented diet under acute stressful conditions, behavioral changes and brain metabolites were compared with mice fed a control diet. In the open field test, no significant difference was observed in locomotor activity among groups. In the elevated plus-maze test, however, significant increases in the percentage of time spent and entries in the open arms were observed in the beta-alanine supplemented diet fed group compared to both controls and animals fed with taurine-supplemented diet. Moreover, a significant decrease in the duration of immobility was observed in the taurine-supplemented diet group in the forced swimming test compared to both controls and animals fed with beta-alanine-supplemented diet. Taurine supplemented diet increased taurine and L-arginine concentrations in the hypothalamus. In contrast, beta-alanine-supplemented diet decreased the concentration of 5-hydroxyindoleacetic acid, a major metabolite of serotonin, in the hypothalamus. Beta-alanine-supplemented diet also increased carnosine (beta-alanyl-L-histidine) concentration in the cerebral cortex and hypothalamus, and brain-derived neurotrophic factor concentration in the hippocampus. These results suggested that taurine-supplemented diet had an antidepressant-like effect and betaalanine-supplemented diet had an anxiolytic-like effect.

本文言語英語
ページ(範囲)427-434
ページ数8
ジャーナルAmino Acids
39
2
DOI
出版ステータス出版済み - 7月 2010

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 臨床生化学
  • 有機化学

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