The improvement of renal survival with steroid pulse therapy in IgA nephropathy

Ritsuko Katafuchi, Toshiharu Ninomiya, Tohru Mizumasa, Kiyoshi Ikeda, Harumitsu Kumagai, Masaharu Nagata, Hideki Hirakata

研究成果: ジャーナルへの寄稿記事

33 引用 (Scopus)

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Background. The benefits of steroid therapy in immunoglobulin A nephropathy (IgAN) have not been established. Methods. The effect of steroids on kidney survival was retrospectively investigated in 702 patients with IgAN by multivariate analyses. Results. There were 295 men and 407 women. The median follow-up period was 62 months. One hundred and ninety-four patients were treated with oral steroids (oral steroid group). Thirty-four patients were treated with methylprednisolone (mPSL) pulse therapy (pulse steroid group) followed by oral prednisolone (PSL). In 474 patients, no steroid was used (no steroid group). The urinary protein-creatinine ratio and histological grade were significantly different among treatment groups and were highest in the pulse steroid group followed by the oral steroid group and lowest in the no steroid patients. Serum creatinine was significantly higher in the pulse steroid group than in other two groups. Eighty-five patients developed end-stage renal failure (ESRF) requiring haemodialysis. In multivariate analysis, steroid pulse therapy significantly decreased the risk of ESRF while oral steroid treatment did not improve renal survival in this cohort. Conclusion. We found that pulse steroid therapy improved kidney survivals in IgAN. Since the clinical findings and histological grade were the most severe in patients treated with mPSL pulse therapy, such therapy may prevent progression of IgAN.

元の言語英語
ページ(範囲)3915-3920
ページ数6
ジャーナルNephrology Dialysis Transplantation
23
発行部数12
DOI
出版物ステータス出版済み - 12 2008

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

これを引用

Katafuchi, R., Ninomiya, T., Mizumasa, T., Ikeda, K., Kumagai, H., Nagata, M., & Hirakata, H. (2008). The improvement of renal survival with steroid pulse therapy in IgA nephropathy. Nephrology Dialysis Transplantation, 23(12), 3915-3920. https://doi.org/10.1093/ndt/gfn394