The inflammation–nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection

Shiki Fujino, Norikatsu Myoshi, Kazuhiro Saso, Msaru Sasaki, Satoshi Ishikawa, Yusuke Takahashi, Masayoshi Yasui, Masayuki Ohue, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki

研究成果: ジャーナルへの寄稿記事

抄録

Purpose: Inflammation and the nutritional and immunologic status are known to be associated with the prognosis of malignant tumors. We aimed to examine inflammation–nutrition scores and predict the prognosis of colorectal cancer (CRC) patients by integrating nutritional and immunologic factors and tumor stage. Methods: This study investigated 511 patients with CRC from 2007 to 2013: 380 in a training set (TS) and 131 in a validation set (VS). The Osaka Prognostic Score (OPS) used comprised 1 point each for C-reactive protein > 1.0 mg/dL, albumin (< 3.5 g/dL), and lymphocyte count < 1600. Patients were classified according to the total points. The modified Glasgow Prognostic Score and the Prognostic Nutritional Index were also examined. A nomogram for predicting the disease-free survival (DFS) and overall survival (OS) was constructed based on the OPS and TNM stage. Results: In the TS, a high OPS and high TNM stage were significant predictors of the DFS and OS. The C-indexes of the OPS for the DFS and OS were higher than those of other reported scoring systems. The C-index of the nomogram for the DFS was 0.762 in the TS and 0.675 in the VS. The C-index of the nomogram for the OS was 0.805 in the TS and 0.743 in the VS. Conclusion: Integrating the TNM stage and OPS accurately predicted the prognosis of patients with CRC.

元の言語英語
ジャーナルSurgery today
DOI
出版物ステータス受理済み/印刷中 - 1 1 2019

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Nomograms
Disease-Free Survival
Colorectal Neoplasms
Survival
Nutrition Assessment
Lymphocyte Count
Immunologic Factors
Nutritional Status
C-Reactive Protein
Albumins
Neoplasms
Inflammation

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

The inflammation–nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection. / Fujino, Shiki; Myoshi, Norikatsu; Saso, Kazuhiro; Sasaki, Msaru; Ishikawa, Satoshi; Takahashi, Yusuke; Yasui, Masayoshi; Ohue, Masayuki; Hata, Taishi; Matsuda, Chu; Mizushima, Tsunekazu; Mori, Masaki; Doki, Yuichiro.

:: Surgery today, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

Fujino, S, Myoshi, N, Saso, K, Sasaki, M, Ishikawa, S, Takahashi, Y, Yasui, M, Ohue, M, Hata, T, Matsuda, C, Mizushima, T, Mori, M & Doki, Y 2019, 'The inflammation–nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection', Surgery today. https://doi.org/10.1007/s00595-019-01861-2
Fujino, Shiki ; Myoshi, Norikatsu ; Saso, Kazuhiro ; Sasaki, Msaru ; Ishikawa, Satoshi ; Takahashi, Yusuke ; Yasui, Masayoshi ; Ohue, Masayuki ; Hata, Taishi ; Matsuda, Chu ; Mizushima, Tsunekazu ; Mori, Masaki ; Doki, Yuichiro. / The inflammation–nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection. :: Surgery today. 2019.
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abstract = "Purpose: Inflammation and the nutritional and immunologic status are known to be associated with the prognosis of malignant tumors. We aimed to examine inflammation–nutrition scores and predict the prognosis of colorectal cancer (CRC) patients by integrating nutritional and immunologic factors and tumor stage. Methods: This study investigated 511 patients with CRC from 2007 to 2013: 380 in a training set (TS) and 131 in a validation set (VS). The Osaka Prognostic Score (OPS) used comprised 1 point each for C-reactive protein > 1.0 mg/dL, albumin (< 3.5 g/dL), and lymphocyte count < 1600. Patients were classified according to the total points. The modified Glasgow Prognostic Score and the Prognostic Nutritional Index were also examined. A nomogram for predicting the disease-free survival (DFS) and overall survival (OS) was constructed based on the OPS and TNM stage. Results: In the TS, a high OPS and high TNM stage were significant predictors of the DFS and OS. The C-indexes of the OPS for the DFS and OS were higher than those of other reported scoring systems. The C-index of the nomogram for the DFS was 0.762 in the TS and 0.675 in the VS. The C-index of the nomogram for the OS was 0.805 in the TS and 0.743 in the VS. Conclusion: Integrating the TNM stage and OPS accurately predicted the prognosis of patients with CRC.",
author = "Shiki Fujino and Norikatsu Myoshi and Kazuhiro Saso and Msaru Sasaki and Satoshi Ishikawa and Yusuke Takahashi and Masayoshi Yasui and Masayuki Ohue and Taishi Hata and Chu Matsuda and Tsunekazu Mizushima and Masaki Mori and Yuichiro Doki",
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T1 - The inflammation–nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection

AU - Fujino, Shiki

AU - Myoshi, Norikatsu

AU - Saso, Kazuhiro

AU - Sasaki, Msaru

AU - Ishikawa, Satoshi

AU - Takahashi, Yusuke

AU - Yasui, Masayoshi

AU - Ohue, Masayuki

AU - Hata, Taishi

AU - Matsuda, Chu

AU - Mizushima, Tsunekazu

AU - Mori, Masaki

AU - Doki, Yuichiro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Inflammation and the nutritional and immunologic status are known to be associated with the prognosis of malignant tumors. We aimed to examine inflammation–nutrition scores and predict the prognosis of colorectal cancer (CRC) patients by integrating nutritional and immunologic factors and tumor stage. Methods: This study investigated 511 patients with CRC from 2007 to 2013: 380 in a training set (TS) and 131 in a validation set (VS). The Osaka Prognostic Score (OPS) used comprised 1 point each for C-reactive protein > 1.0 mg/dL, albumin (< 3.5 g/dL), and lymphocyte count < 1600. Patients were classified according to the total points. The modified Glasgow Prognostic Score and the Prognostic Nutritional Index were also examined. A nomogram for predicting the disease-free survival (DFS) and overall survival (OS) was constructed based on the OPS and TNM stage. Results: In the TS, a high OPS and high TNM stage were significant predictors of the DFS and OS. The C-indexes of the OPS for the DFS and OS were higher than those of other reported scoring systems. The C-index of the nomogram for the DFS was 0.762 in the TS and 0.675 in the VS. The C-index of the nomogram for the OS was 0.805 in the TS and 0.743 in the VS. Conclusion: Integrating the TNM stage and OPS accurately predicted the prognosis of patients with CRC.

AB - Purpose: Inflammation and the nutritional and immunologic status are known to be associated with the prognosis of malignant tumors. We aimed to examine inflammation–nutrition scores and predict the prognosis of colorectal cancer (CRC) patients by integrating nutritional and immunologic factors and tumor stage. Methods: This study investigated 511 patients with CRC from 2007 to 2013: 380 in a training set (TS) and 131 in a validation set (VS). The Osaka Prognostic Score (OPS) used comprised 1 point each for C-reactive protein > 1.0 mg/dL, albumin (< 3.5 g/dL), and lymphocyte count < 1600. Patients were classified according to the total points. The modified Glasgow Prognostic Score and the Prognostic Nutritional Index were also examined. A nomogram for predicting the disease-free survival (DFS) and overall survival (OS) was constructed based on the OPS and TNM stage. Results: In the TS, a high OPS and high TNM stage were significant predictors of the DFS and OS. The C-indexes of the OPS for the DFS and OS were higher than those of other reported scoring systems. The C-index of the nomogram for the DFS was 0.762 in the TS and 0.675 in the VS. The C-index of the nomogram for the OS was 0.805 in the TS and 0.743 in the VS. Conclusion: Integrating the TNM stage and OPS accurately predicted the prognosis of patients with CRC.

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