抄録
Purpose: Inflammation and the nutritional and immunologic status are known to be associated with the prognosis of malignant tumors. We aimed to examine inflammation–nutrition scores and predict the prognosis of colorectal cancer (CRC) patients by integrating nutritional and immunologic factors and tumor stage. Methods: This study investigated 511 patients with CRC from 2007 to 2013: 380 in a training set (TS) and 131 in a validation set (VS). The Osaka Prognostic Score (OPS) used comprised 1 point each for C-reactive protein > 1.0 mg/dL, albumin (< 3.5 g/dL), and lymphocyte count < 1600. Patients were classified according to the total points. The modified Glasgow Prognostic Score and the Prognostic Nutritional Index were also examined. A nomogram for predicting the disease-free survival (DFS) and overall survival (OS) was constructed based on the OPS and TNM stage. Results: In the TS, a high OPS and high TNM stage were significant predictors of the DFS and OS. The C-indexes of the OPS for the DFS and OS were higher than those of other reported scoring systems. The C-index of the nomogram for the DFS was 0.762 in the TS and 0.675 in the VS. The C-index of the nomogram for the OS was 0.805 in the TS and 0.743 in the VS. Conclusion: Integrating the TNM stage and OPS accurately predicted the prognosis of patients with CRC.
| 元の言語 | 英語 |
|---|---|
| ジャーナル | Surgery today |
| DOI | |
| 出版物ステータス | 受理済み/印刷中 - 1 1 2019 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Surgery
これを引用
The inflammation–nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection. / Fujino, Shiki; Myoshi, Norikatsu; Saso, Kazuhiro; Sasaki, Msaru; Ishikawa, Satoshi; Takahashi, Yusuke; Yasui, Masayoshi; Ohue, Masayuki; Hata, Taishi; Matsuda, Chu; Mizushima, Tsunekazu; Mori, Masaki; Doki, Yuichiro.
：: Surgery today, 01.01.2019.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - The inflammation–nutrition score supports the prognostic prediction of the TNM stage for colorectal cancer patients after curative resection
AU - Fujino, Shiki
AU - Myoshi, Norikatsu
AU - Saso, Kazuhiro
AU - Sasaki, Msaru
AU - Ishikawa, Satoshi
AU - Takahashi, Yusuke
AU - Yasui, Masayoshi
AU - Ohue, Masayuki
AU - Hata, Taishi
AU - Matsuda, Chu
AU - Mizushima, Tsunekazu
AU - Mori, Masaki
AU - Doki, Yuichiro
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: Inflammation and the nutritional and immunologic status are known to be associated with the prognosis of malignant tumors. We aimed to examine inflammation–nutrition scores and predict the prognosis of colorectal cancer (CRC) patients by integrating nutritional and immunologic factors and tumor stage. Methods: This study investigated 511 patients with CRC from 2007 to 2013: 380 in a training set (TS) and 131 in a validation set (VS). The Osaka Prognostic Score (OPS) used comprised 1 point each for C-reactive protein > 1.0 mg/dL, albumin (< 3.5 g/dL), and lymphocyte count < 1600. Patients were classified according to the total points. The modified Glasgow Prognostic Score and the Prognostic Nutritional Index were also examined. A nomogram for predicting the disease-free survival (DFS) and overall survival (OS) was constructed based on the OPS and TNM stage. Results: In the TS, a high OPS and high TNM stage were significant predictors of the DFS and OS. The C-indexes of the OPS for the DFS and OS were higher than those of other reported scoring systems. The C-index of the nomogram for the DFS was 0.762 in the TS and 0.675 in the VS. The C-index of the nomogram for the OS was 0.805 in the TS and 0.743 in the VS. Conclusion: Integrating the TNM stage and OPS accurately predicted the prognosis of patients with CRC.
AB - Purpose: Inflammation and the nutritional and immunologic status are known to be associated with the prognosis of malignant tumors. We aimed to examine inflammation–nutrition scores and predict the prognosis of colorectal cancer (CRC) patients by integrating nutritional and immunologic factors and tumor stage. Methods: This study investigated 511 patients with CRC from 2007 to 2013: 380 in a training set (TS) and 131 in a validation set (VS). The Osaka Prognostic Score (OPS) used comprised 1 point each for C-reactive protein > 1.0 mg/dL, albumin (< 3.5 g/dL), and lymphocyte count < 1600. Patients were classified according to the total points. The modified Glasgow Prognostic Score and the Prognostic Nutritional Index were also examined. A nomogram for predicting the disease-free survival (DFS) and overall survival (OS) was constructed based on the OPS and TNM stage. Results: In the TS, a high OPS and high TNM stage were significant predictors of the DFS and OS. The C-indexes of the OPS for the DFS and OS were higher than those of other reported scoring systems. The C-index of the nomogram for the DFS was 0.762 in the TS and 0.675 in the VS. The C-index of the nomogram for the OS was 0.805 in the TS and 0.743 in the VS. Conclusion: Integrating the TNM stage and OPS accurately predicted the prognosis of patients with CRC.
UR - http://www.scopus.com/inward/record.url?scp=85070672042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070672042&partnerID=8YFLogxK
U2 - 10.1007/s00595-019-01861-2
DO - 10.1007/s00595-019-01861-2
M3 - Article
AN - SCOPUS:85070672042
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
ER -