The Influence of Clinical T Factor on Predicting Pathologic N Factor in Resected Lung Cancer

Shinichiro Shimamatsu, Mitsuhiro Takenoyama, Mototsugu Shimokawa, Kazuki Takada, Makoto Edagawa, Ryo Toyozawa, Kaname Nosaki, Taro Oba, Tetsuzo Tagawa, Masafumi Yamaguchi, Kenichi Taguchi, Takashi Seto

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Background: We investigated the utility of the clinical T factor of the 8th edition of the TNM classification, which newly defines the consolidation size of the tumor, as a valuable predictor of pathologic lymph node metastasis (pN+) and the prognosis. Methods: We retrospectively reviewed 825 patients with surgically resected cN0 M0 non-small cell lung cancer of any T stage, focusing on the tumor's total size (7th edition) and consolidation size (8th edition) and examined pN+ and the prognosis. Results: No pN+ cases in the 7th or 8th edition groups had a tumor size of less than 1 cm, and in those sized 1 to 3 cm, the frequency of pN+ in the 7th and 8th edition groups was 10.3% and 13.4%, respectively. The frequency of pN+ in tumors without ground glass opacity (GGO−) was 5.5-times higher than that of tumors with GGO (GGO+). The frequency of pN+ in the GGO+ 8th edition group was twice that in the GGO+ 7th edition group. The frequency of pN+ in the GGO− 7th edition group was 4-times higher than that of the GGO+ 7th edition group. A multivariate analysis revealed that total size exceeding 2 cm, consolidation size exceeding 2 cm, and GGO− were significant predictors of a pN+ status, indicating that a consolidation size of more than 2 cm was a stronger predictor than a total size of more than 2 cm. Conclusions: A consolidation size of more than 2 cm and GGO− were predictors of pN+, and the clinical T factor of the 8th Edition was a stronger predictor of the pN+ status than that of the 7th edition.

元の言語英語
ページ(範囲)1080-1086
ページ数7
ジャーナルAnnals of Thoracic Surgery
108
発行部数4
DOI
出版物ステータス出版済み - 10 2019

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Shimamatsu, S., Takenoyama, M., Shimokawa, M., Takada, K., Edagawa, M., Toyozawa, R., Nosaki, K., Oba, T., Tagawa, T., Yamaguchi, M., Taguchi, K., & Seto, T. (2019). The Influence of Clinical T Factor on Predicting Pathologic N Factor in Resected Lung Cancer. Annals of Thoracic Surgery, 108(4), 1080-1086. https://doi.org/10.1016/j.athoracsur.2019.04.026