The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati, Taslim Ersam, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.

本文言語英語
ページ(範囲)49-51
ページ数3
ジャーナルPhytomedicine
22
1
DOI
出版ステータス出版済み - 3 2015

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療

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