The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells

Enos Tangke Arung, Shoko Furuta, Kazuhiro Sugamoto, Kuniyoshi Shimizu, Hiroya Ishikawa, Yoh Ichi Matsushita, Ryuichiro Kondo

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.

本文言語英語
ページ(範囲)1007-1010
ページ数4
ジャーナルNatural product communications
7
8
DOI
出版ステータス出版済み - 8 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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