The interaction of sulfonated sugars with amyloid peptide of Aβ(1-42) and PrP(106-126)

Kikuko Yasuda, Mihoko Koike, Yoshiko Miura, Yoshihiro Nishida, Kazukiyo Kobayashi

研究成果: 会議への寄与タイプ学会誌査読

1 被引用数 (Scopus)

抄録

Biological active saccharide of proteoglycans and gangliosides has been reported to accelate the amyloid formation of Alzheimer peptide. Those reports indicated the strong interaction with Aβ.We have reported the synthesis and biological activity of sulfonated sugars for a sialic acid mimic.Here,we investigate the interaction between sulfonated GIcNAc and Aβ. The aggregation of Aβ with heparin and pNP 6-sulfo-GIcNAc was estimated by fluorescence of thioflavin T,CD spectra and TEM observations. Though heparin induced the aggregation and β-sheet conformation. pNP 6-sulfo-GIcNAc inhibited them.

本文言語英語
ページ数1
出版ステータス出版済み - 12月 1 2005
外部発表はい
イベント54th SPSJ Symposium on Macromolecules - Yamagata, 日本
継続期間: 9月 20 20059月 22 2005

その他

その他54th SPSJ Symposium on Macromolecules
国/地域日本
CityYamagata
Period9/20/059/22/05

!!!All Science Journal Classification (ASJC) codes

  • 工学(全般)

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