The involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II in the circadian rhythms controlled by the suprachiasmatic nucleus

Tatsuto Fukushima, Takao Shimazoe, Shigenobu Shibata, Akihito Watanabe, Michiko Ono, Toshiyuki Hamada, Shigenori Watanabe

研究成果: ジャーナルへの寄稿記事

36 引用 (Scopus)

抄録

We investigated the involvement of calmodulin and Ca2+/calmodulin- dependent protein kinase II (CaMKII) in the photic entrainment of circadian rhythms using calmodulin inhibitors such as calmidazolium (CMZ) and trifluoperazine (TFP), and a CaMKII inhibitor, KN-62, in rats. Fos expression in the suprachiasmatic nucleus (SCN) of rats induced by photic stimulation (300 lux, 1 h) during the early subjective night of the rats was inhibited by treatment with CMZ (10 mg/kg i.p.) or TFP (20 mg/kg i.p.) 30 min before photic stimulation. With respect to the neuronal firing rate in the rat SCN slice, KN-62 and CMZ application during the early subjective night attenuated the glutamate (10 μM)-induced phase shift. The present results suggest that calmodulin and CaMKII are involved in the photic entrainment mechanism in the rodent SCN.

元の言語英語
ページ(範囲)45-48
ページ数4
ジャーナルNeuroscience Letters
227
発行部数1
DOI
出版物ステータス出版済み - 5 9 1997

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calmidazolium
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Suprachiasmatic Nucleus
KN 62
Calmodulin
Circadian Rhythm
Trifluoperazine
Photic Stimulation
Protein Kinase Inhibitors
Cell Division
Glutamic Acid
Rodentia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

The involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II in the circadian rhythms controlled by the suprachiasmatic nucleus. / Fukushima, Tatsuto; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Akihito; Ono, Michiko; Hamada, Toshiyuki; Watanabe, Shigenori.

:: Neuroscience Letters, 巻 227, 番号 1, 09.05.1997, p. 45-48.

研究成果: ジャーナルへの寄稿記事

Fukushima, Tatsuto ; Shimazoe, Takao ; Shibata, Shigenobu ; Watanabe, Akihito ; Ono, Michiko ; Hamada, Toshiyuki ; Watanabe, Shigenori. / The involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II in the circadian rhythms controlled by the suprachiasmatic nucleus. :: Neuroscience Letters. 1997 ; 巻 227, 番号 1. pp. 45-48.
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