The involvement of gamma delta T cells in neurological disorders

Several studies have demonstrated that gamma delta T cells increased during infections with various Pathogens. A significant fraction of these gamma delta T cells are specialized in recognizing mycobacterial antigen, in particular, 65 kda heat-shock protein (Hsp), which is highly conserved between bacteria and eukaryotes. The demonstrated immunogenicity of a number of hsp has led to their being implicated in diseases of possible autoimmune etiology. A possible role of gamma delta T cells in human autoimmune diseases such as rheumatoid arthritis, diabetes, polymyositis, sarcoidosis and acute or chronic multiple sclerosis has been previously proposed. In this brief review, we summarized the current understandings of the immunobiology of gamma delta T cells focusing on the involvement of autoimmune processes.