The involvement of IL-23 and the Th 17 pathway in periodontitis

H. Ohyama, N. Kato-Kogoe, A. Kuhara, F. Nishimura, K. Nakasho, K. Yamanegi, N. Yamada, M. Hata, J. Yamane, N. Terada

研究成果: ジャーナルへの寄稿学術誌査読

136 被引用数 (Scopus)

抄録

Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in periodontal lesions and control sites. IL-23 and IL-12 were expressed at significantly higher levels in periodontal lesions than in control sites. However, the relative expression of the IL-23 receptor compared with the IL-12 receptor β2 was significantly higher in periodontal lesions. Moreover, IL-17 expression was significantly higher in periodontal lesions, especially in the tissue adjacent to bone destruction, than in control sites. There was no significant difference in the expression levels of IFN-γ, an important cytokine inhibiting differentiation toward the Th17 pathway, between periodontal lesions and control sites. Together, these results suggest that the IL-23-induced Th17 pathway is stimulated in inflammatory periodontal lesions.

本文言語英語
ページ(範囲)633-638
ページ数6
ジャーナルJournal of Dental Research
88
7
DOI
出版ステータス出版済み - 7月 1 2009
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 歯科学(全般)

フィンガープリント

「The involvement of IL-23 and the Th 17 pathway in periodontitis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル