The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

Raffi V. Aroian, Makoto Koga, Jane E. Mendel, Yasumi Ohshima, Paul W. Sternberg

研究成果: Contribution to journalArticle査読

326 被引用数 (Scopus)

抄録

The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.

本文言語英語
ページ(範囲)693-699
ページ数7
ジャーナルNature
348
6303
DOI
出版ステータス出版済み - 1990

All Science Journal Classification (ASJC) codes

  • 一般

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