The life cycle of the GABAA receptor and its regulating molecules

Takashi Kanematsu, Miho Terunuma, Hidefumi Goto, Akiko Kuratani, Masato Hirata

研究成果: Contribution to journalReview article査読

抄録

γ-Aminobutyric acidA (GABAA) receptors mediate most of the fast inhibitory neurotransmission in the central nervous system. These ligand-gated ion channels are crucial in the control of cell and network activity. Therefore, modulating their function or cell surface stability will have major consequences for neuronal excitation. This review highlights recent findings on the regulation of GABAA-receptor expression and function, focusing on the mechanisms of sorting, targeting, synaptic clustering, and endocytic events of GABAA receptors, all which are regulated by their associated proteins. Now these topics are an area of active interest in studies on inhibitory neurotransmission.

本文言語英語
ページ(範囲)105-112
ページ数8
ジャーナルFolia Pharmacologica Japonica
123
2
DOI
出版ステータス出版済み - 2 23 2004

All Science Journal Classification (ASJC) codes

  • Pharmacology

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