The light and dark side of bisphosphonates

Eijiro Jimi, Masamichi Takami, Toru Hiraga, Ichiro Nakamura, Masahiro Urade, Yoichi Miyamoto

研究成果: Contribution to journalReview article査読

2 被引用数 (Scopus)

抄録

Bisphosphonates are stable compounds of pyrophosphoric acid that inhibit hydroxyapatite formation. This class of chemical was first investigated in the 1960s for use in the treatment of disorders of bone metabolism. Bisphosphonates have been developed for clinical use since then, and, currently, the third, nitrogen-containing, generation of bisphosphonates is widely used for the treatment of various bone diseases, including osteoporosis and bone metastases in cancer. However, despite the therapeutic benefits, the emergence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a growing and significant problem in a subset of patients receiving these drugs. In this review, we introduce the benefits and risks of bisphosphonates,"the light and dark side"so to speak, to facilitate a full understanding of these compounds.

本文言語英語
ページ(範囲)177-187
ページ数11
ジャーナルjournal of oral biosciences
51
4
DOI
出版ステータス出版済み - 11 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 歯科学(全般)
  • 生化学、遺伝学、分子生物学(全般)

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