The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice

Shinichi Nakagawa, Masayuki Shimada, Kaori Yanaka, Mari Mito, Takashi Arai, Eiki Takahashi, Youko Fujita, Toshihiko Fujimori, Laura Standaert, Jean Christophe Marine, Tetsuro Hirose

研究成果: Contribution to journalArticle査読

148 被引用数 (Scopus)

抄録

Neat1 is a non-protein-coding RNA that serves as an architectural component of the nuclear bodies known as paraspeckles. Although cell-based studies indicate that Neat1 is a crucial regulator of gene expression, its physiological relevance remains unclear. Here, we find that Neat1 knockout (KO) mice stochastically fail to become pregnant despite normal ovulation. Unilateral transplantation of wild-type ovaries or the administration of progesterone partially rescued the phenotype, suggesting that corpus luteum dysfunction and concomitant low progesterone were the primary causes of the decreased fertility. In contrast to the faint expression observed in most of the adult tissues, Neat1 was highly expressed in the corpus luteum, and the formation of luteal tissue was severely impaired in nearly half of the Neat1 KO mice. These observations suggest that Neat1 is essential for the formation of the corpus luteum and for the subsequent establishment of pregnancy under a suboptimal condition that has not yet been identified.

本文言語英語
ページ(範囲)4618-4627
ページ数10
ジャーナルDevelopment (Cambridge)
141
23
DOI
出版ステータス出版済み - 12 1 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 発生生物学

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