The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition

Ryo Furukawa, Yuma Yamada, Yuichi Matsushima, Yu Ichi Goto, Hideyoshi Harashima

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

For successful mitochondrial transgene expression, an optimal packaging exogenous DNA is an important issue. We report herein on the effects of DNA packaged with mitochondrial transcription factor A (TFAM), which packages mitochondrial DNA (mtDNA), on the transcription process. Our initial findings indicated that the transcription of the TFAM/DNA complex was activated, when the complex was formed at an optimal ratio. We also found that TFAM has a significant advantage over protamine, a nuclear DNA packaging protein, from the viewpoint of transcription efficiency. This result indicates that TFAM can be useful packaging protein for exogenous DNA to achieve mitochondrial transgene expression.

本文言語英語
ページ(範囲)145-150
ページ数6
ジャーナルFEBS Open Bio
2
DOI
出版ステータス出版済み - 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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