The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Hiroyuki Kitao, Shinichi Kiyonari, Makoto Limori, Shinichiro Niimi, Yuki Kataoka, Shingo Akiyama, Keitaro Edahiro, Ryota Nakanishi, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Shingo Kanaji, Yoshihiro Kakeji, Yoshihiko Maehara

研究成果: Contribution to journalReview article査読

3 被引用数 (Scopus)

抄録

Platinum-based chemotherapeutic drugs as a component of combination chemotherapy are widely used in the treatment of cancer. In particular, oxaliplatin (L-OHP), one such platinum-based chemotherapeutic drug, has a synergistic effect in combination with 5-FU and Leucovorin for the treatment of advanced colorectal cancer. However, the underlying molecular mechanism of this synergistic effect has not been fully clarified yet. In this review, we summarize several updates about the in vitro action of oxaliplatin in human tumor cells and discuss the underlying mechanism of its synergistic effect with 5-FU.

本文言語英語
ページ(範囲)707-714
ページ数8
ジャーナルJapanese Journal of Cancer and Chemotherapy
43
6
出版ステータス出版済み - 6 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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