The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Hiroyuki Kitao; Shinichi Kiyonari; Makoto Limori; Shinichiro Niimi; Yuki Kataoka; Shingo Akiyama; Keitaro Edahiro; Ryota Nakanishi; Eriko Tokunaga; Hiroshi Saeki; Eiji Oki; Shingo Kanaji; Yoshihiro Kakeji; Yoshihiko Maehara

The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Hiroyuki Kitao, Shinichi Kiyonari, Makoto Limori, Shinichiro Niimi, Yuki Kataoka, Shingo Akiyama, Keitaro Edahiro, Ryota Nakanishi, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Shingo Kanaji, Yoshihiro Kakeji, Yoshihiko Maehara

研究成果: Contribution to journal › Review article › 査読

3 被引用数 (Scopus)

抄録

Platinum-based chemotherapeutic drugs as a component of combination chemotherapy are widely used in the treatment of cancer. In particular, oxaliplatin (L-OHP), one such platinum-based chemotherapeutic drug, has a synergistic effect in combination with 5-FU and Leucovorin for the treatment of advanced colorectal cancer. However, the underlying molecular mechanism of this synergistic effect has not been fully clarified yet. In this review, we summarize several updates about the in vitro action of oxaliplatin in human tumor cells and discuss the underlying mechanism of its synergistic effect with 5-FU.

本文言語	英語
ページ（範囲）	707-714
ページ数	8
ジャーナル	Japanese Journal of Cancer and Chemotherapy
巻	43
号	6
出版ステータス	出版済み - 6 2016

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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引用スタイル

The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU. / Kitao, Hiroyuki; Kiyonari, Shinichi; Limori, Makoto; Niimi, Shinichiro; Kataoka, Yuki; Akiyama, Shingo; Edahiro, Keitaro; Nakanishi, Ryota; Tokunaga, Eriko; Saeki, Hiroshi; Oki, Eiji; Kanaji, Shingo; Kakeji, Yoshihiro; Maehara, Yoshihiko.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 43, No. 6, 06.2016, p. 707-714.

研究成果: Contribution to journal › Review article › 査読

Kitao, Hiroyuki ; Kiyonari, Shinichi ; Limori, Makoto ; Niimi, Shinichiro ; Kataoka, Yuki ; Akiyama, Shingo ; Edahiro, Keitaro ; Nakanishi, Ryota ; Tokunaga, Eriko ; Saeki, Hiroshi ; Oki, Eiji ; Kanaji, Shingo ; Kakeji, Yoshihiro ; Maehara, Yoshihiko. / The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU. In: Japanese Journal of Cancer and Chemotherapy. 2016 ; Vol. 43, No. 6. pp. 707-714.

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abstract = "Platinum-based chemotherapeutic drugs as a component of combination chemotherapy are widely used in the treatment of cancer. In particular, oxaliplatin (L-OHP), one such platinum-based chemotherapeutic drug, has a synergistic effect in combination with 5-FU and Leucovorin for the treatment of advanced colorectal cancer. However, the underlying molecular mechanism of this synergistic effect has not been fully clarified yet. In this review, we summarize several updates about the in vitro action of oxaliplatin in human tumor cells and discuss the underlying mechanism of its synergistic effect with 5-FU.",

author = "Hiroyuki Kitao and Shinichi Kiyonari and Makoto Limori and Shinichiro Niimi and Yuki Kataoka and Shingo Akiyama and Keitaro Edahiro and Ryota Nakanishi and Eriko Tokunaga and Hiroshi Saeki and Eiji Oki and Shingo Kanaji and Yoshihiro Kakeji and Yoshihiko Maehara",

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AU - Kitao, Hiroyuki

AU - Kiyonari, Shinichi

AU - Limori, Makoto

AU - Niimi, Shinichiro

AU - Kataoka, Yuki

AU - Akiyama, Shingo

AU - Edahiro, Keitaro

AU - Nakanishi, Ryota

AU - Tokunaga, Eriko

AU - Saeki, Hiroshi

AU - Oki, Eiji

AU - Kanaji, Shingo

AU - Kakeji, Yoshihiro

AU - Maehara, Yoshihiko

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