The molecular pathogenesis of collagen-induced arthritis in mice - A model for rheumatoid arthritis

Rikard Holmdahl, Robert Bockermann, Johan Bäcklund, Hisakata Yamada

研究成果: Contribution to journalReview article査読

129 被引用数 (Scopus)

抄録

The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFα neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis.

本文言語英語
ページ(範囲)135-147
ページ数13
ジャーナルAgeing Research Reviews
1
1
DOI
出版ステータス出版済み - 2 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Ageing
  • Molecular Biology
  • Neurology

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