The NADPH oxidase Nox4 and aging in the heart

Tetsuro Ago, Shouji Matsushima, Junya Kuroda, Daniela Zablocki, Takanari Kitazono, Junichi Sadoshima

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

抜粋

Oxidative stress in mitochondria is believed to promote aging. Although passive leakage of electron from the m itochondrial electron transport chain has been considered as a major source of oxidative stress in the heart and the cardiomyocytes therein, enzymes actively producing reactive oxygen species may also exist in mitochondria. We have shown recently that Nox4, a member of the NADPH oxidase family, is localized on intracellular membranes, primarily at mitochondria, in cardiomyocytes. Mitochondrial expression of Nox4 is upregulated by cardiac stress and aging in the heart, where Nox4 could become a major source of oxidative stress. This raises an intriguing possibility that Nox4 may play an important role in mediating aging of the heart. Here we discuss the potential involvement of Nox4 in mitochondrial oxidative stress and aging in the heart.

元の言語英語
ページ(範囲)1012-1016
ページ数5
ジャーナルAging
2
発行部数12
DOI
出版物ステータス出版済み - 12 2010

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cell Biology

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