The neurovascular unit in health and ischemic stroke

研究成果: ジャーナルへの寄稿評論記事

2 引用 (Scopus)

抄録

The neurovascular unit (NVU), a minimal unit to exert neurological functions, is composed of neurons, astrocytes, endothelial cells, pericytes, and extracellular matrix proteins forming basal membranes. The cell components interact with one another and function cooperatively under both physiological and pathological conditions. Pericytes and astrocytes participate crucially in the formation and maintenance of the blood-brain barrier (BBB), the tight junction formed by endothelial cells, and regulate cerebral blood flow in response to neurological activities. The BBB actively regulate molecular import and export. The concept of the NVU is also useful for understanding pathogenesis and exploring therapeutic targets in various CNS disorders. In this review, recent research advances regarding the NVU and its components in health and ischemic stroke are summarized.

元の言語英語
ページ(範囲)583-588
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
74
発行部数4
出版物ステータス出版済み - 4 1 2016

Fingerprint

Pericytes
Blood-Brain Barrier
Astrocytes
Cerebrovascular Circulation
Endothelial Cells
Stroke
Tight Junctions
Extracellular Matrix Proteins
Health
Cellular Structures
Maintenance
Neurons
Membranes
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

The neurovascular unit in health and ischemic stroke. / Ago, Tetsuro.

:: Nippon rinsho. Japanese journal of clinical medicine, 巻 74, 番号 4, 01.04.2016, p. 583-588.

研究成果: ジャーナルへの寄稿評論記事

@article{553e656fdef540719fb7e43ea1eb5d1a,
title = "The neurovascular unit in health and ischemic stroke",
abstract = "The neurovascular unit (NVU), a minimal unit to exert neurological functions, is composed of neurons, astrocytes, endothelial cells, pericytes, and extracellular matrix proteins forming basal membranes. The cell components interact with one another and function cooperatively under both physiological and pathological conditions. Pericytes and astrocytes participate crucially in the formation and maintenance of the blood-brain barrier (BBB), the tight junction formed by endothelial cells, and regulate cerebral blood flow in response to neurological activities. The BBB actively regulate molecular import and export. The concept of the NVU is also useful for understanding pathogenesis and exploring therapeutic targets in various CNS disorders. In this review, recent research advances regarding the NVU and its components in health and ischemic stroke are summarized.",
author = "Tetsuro Ago",
year = "2016",
month = "4",
day = "1",
language = "English",
volume = "74",
pages = "583--588",
journal = "Astrophysical Journal",
issn = "0004-637X",
publisher = "IOP Publishing Ltd.",
number = "4",

}

TY - JOUR

T1 - The neurovascular unit in health and ischemic stroke

AU - Ago, Tetsuro

PY - 2016/4/1

Y1 - 2016/4/1

N2 - The neurovascular unit (NVU), a minimal unit to exert neurological functions, is composed of neurons, astrocytes, endothelial cells, pericytes, and extracellular matrix proteins forming basal membranes. The cell components interact with one another and function cooperatively under both physiological and pathological conditions. Pericytes and astrocytes participate crucially in the formation and maintenance of the blood-brain barrier (BBB), the tight junction formed by endothelial cells, and regulate cerebral blood flow in response to neurological activities. The BBB actively regulate molecular import and export. The concept of the NVU is also useful for understanding pathogenesis and exploring therapeutic targets in various CNS disorders. In this review, recent research advances regarding the NVU and its components in health and ischemic stroke are summarized.

AB - The neurovascular unit (NVU), a minimal unit to exert neurological functions, is composed of neurons, astrocytes, endothelial cells, pericytes, and extracellular matrix proteins forming basal membranes. The cell components interact with one another and function cooperatively under both physiological and pathological conditions. Pericytes and astrocytes participate crucially in the formation and maintenance of the blood-brain barrier (BBB), the tight junction formed by endothelial cells, and regulate cerebral blood flow in response to neurological activities. The BBB actively regulate molecular import and export. The concept of the NVU is also useful for understanding pathogenesis and exploring therapeutic targets in various CNS disorders. In this review, recent research advances regarding the NVU and its components in health and ischemic stroke are summarized.

UR - http://www.scopus.com/inward/record.url?scp=84979093281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979093281&partnerID=8YFLogxK

M3 - Review article

C2 - 27333744

AN - SCOPUS:84979093281

VL - 74

SP - 583

EP - 588

JO - Astrophysical Journal

JF - Astrophysical Journal

SN - 0004-637X

IS - 4

ER -