The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Wataru Mizushima, Hidehisa Takahashi, Masashi Watanabe, Shintaro Kinugawa, Shouji Matsushima, Shingo Takada, Takashi Yokota, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Ikuru Chiba, Shun Nagashima, Shigeru Yanagi, Masaki Matsumoto, Keiichi I. Nakayama, Hiroyuki Tsutsui, Shigetsugu Hatakeyama

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

A failing heart shows severe energy insufficiency, and it is presumed that this energy shortage plays a critical role in the development of cardiac dysfunction. However, little is known about the mechanisms that cause energy metabolic alterations in the failing heart. Here, we show that the novel RING-finger protein 207 (RNF207), which is specifically expressed in the heart, plays a role in cardiac energy metabolism. Depletion of RNF207 in neonatal rat cardiomyocytes (NRCs) leads to a reduced cellular concentration of adenosine triphosphate (ATP) and mitochondrial dysfunction. Consistent with this result, we observed here that the expression of RNF207 was significantly reduced in mice with common cardiac diseases including heart failure. Intriguingly, proteomic approaches revealed that RNF207 interacts with the voltage-dependent anion channel (VDAC), which is considered to be a key regulator of mitochondria function, as an RNF207-interacting protein. Our findings indicate that RNF207 is involved in ATP production by cardiomyocytes, suggesting that RNF207 plays an important role in the development of heart failure.

元の言語英語
ページ(範囲)43-53
ページ数11
ジャーナルJournal of Molecular and Cellular Cardiology
100
DOI
出版物ステータス出版済み - 11 1 2016

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Cardiac Myocytes
Energy Metabolism
Fingers
Proteins
Heart Failure
Adenosine Triphosphate
Voltage-Dependent Anion Channels
Proteomics
Heart Diseases
Mitochondria

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

これを引用

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. / Mizushima, Wataru; Takahashi, Hidehisa; Watanabe, Masashi; Kinugawa, Shintaro; Matsushima, Shouji; Takada, Shingo; Yokota, Takashi; Furihata, Takaaki; Matsumoto, Junichi; Tsuda, Masaya; Chiba, Ikuru; Nagashima, Shun; Yanagi, Shigeru; Matsumoto, Masaki; Nakayama, Keiichi I.; Tsutsui, Hiroyuki; Hatakeyama, Shigetsugu.

:: Journal of Molecular and Cellular Cardiology, 巻 100, 01.11.2016, p. 43-53.

研究成果: ジャーナルへの寄稿記事

Mizushima, W, Takahashi, H, Watanabe, M, Kinugawa, S, Matsushima, S, Takada, S, Yokota, T, Furihata, T, Matsumoto, J, Tsuda, M, Chiba, I, Nagashima, S, Yanagi, S, Matsumoto, M, Nakayama, KI, Tsutsui, H & Hatakeyama, S 2016, 'The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes', Journal of Molecular and Cellular Cardiology, 巻. 100, pp. 43-53. https://doi.org/10.1016/j.yjmcc.2016.09.013
Mizushima, Wataru ; Takahashi, Hidehisa ; Watanabe, Masashi ; Kinugawa, Shintaro ; Matsushima, Shouji ; Takada, Shingo ; Yokota, Takashi ; Furihata, Takaaki ; Matsumoto, Junichi ; Tsuda, Masaya ; Chiba, Ikuru ; Nagashima, Shun ; Yanagi, Shigeru ; Matsumoto, Masaki ; Nakayama, Keiichi I. ; Tsutsui, Hiroyuki ; Hatakeyama, Shigetsugu. / The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. :: Journal of Molecular and Cellular Cardiology. 2016 ; 巻 100. pp. 43-53.
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AU - Takada, Shingo

AU - Yokota, Takashi

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AU - Nagashima, Shun

AU - Yanagi, Shigeru

AU - Matsumoto, Masaki

AU - Nakayama, Keiichi I.

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