TY - JOUR
T1 - The nucleoid protein H-NS facilitates chromosome DNA replication in Escherichia coli dnaA mutants
AU - Katayama, Tsutomu
AU - Takata, Makoto
AU - Sekimizu, Kazuhisa
PY - 1996
Y1 - 1996
N2 - Growth inhibition of the dnaA(Cs) mutant, which overinitiates chromosome replication, was shown to be dependent upon the nucleoid protein H-NS. [3H]thymine incorporation experiments indicated that the absence of H-NS inhibited overreplication by the dnaA(Cs) mutant. In addition, the temperature-sensitive phenotype of a dnaA46 mutant was enhanced by disruption of H-NS. These observations suggest that H-NS directly or indirectly facilitates the initiation of chromosome replication.
AB - Growth inhibition of the dnaA(Cs) mutant, which overinitiates chromosome replication, was shown to be dependent upon the nucleoid protein H-NS. [3H]thymine incorporation experiments indicated that the absence of H-NS inhibited overreplication by the dnaA(Cs) mutant. In addition, the temperature-sensitive phenotype of a dnaA46 mutant was enhanced by disruption of H-NS. These observations suggest that H-NS directly or indirectly facilitates the initiation of chromosome replication.
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U2 - 10.1128/jb.178.19.5790-5792.1996
DO - 10.1128/jb.178.19.5790-5792.1996
M3 - Article
C2 - 8824628
AN - SCOPUS:0029797932
VL - 178
SP - 5790
EP - 5792
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 19
ER -